Concept
Génétique inverse
Publications associées (36)
Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics
Camille Véronique Bernadette Goemans, Florian Huber
By acquiring or evolving resistance to one antibiotic, bacteria can become resistant to a second one, due to shared underlying mechanisms. This is called cross-resistance (XR) and further limits therapeutic choices. The opposite scenario, in which initial ...
2024Diet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population
Johan Auwerx, Evan Graehl Williams
The BXD family has become one of the preeminent genetic reference populations to understand the genetic and environmental control of phenotypic variation. Here we evaluate the responses to different levels of fat in the diet using both chow diet (CD, 13-18 ...
PUBLIC LIBRARY SCIENCE2019Systems genetics approaches to probe gene function
Genes are the functional units of heredity. However, the functions of many genes remain unknown, which impedes the understanding of the underlying mechanism of complex traits and diseases. Systems genetics approaches try to understand the complexity underl ...
EPFL2019Genetic characterization of an adapted pandemic 2009 H1N1 influenza virus that reveals improved replication rates in human lung epithelial cells
The 2009 influenza pandemic originated from a swine-origin H1N1 virus, which, although less pathogenic than anticipated, may acquire additional virulence-associated mutations in the future. To estimate the potential risk, we sequentially passaged the isola ...
Academic Press Inc Elsevier Science2016Astrocyte scar formation aids central nervous system axon regeneration
Mark Andrew Anderson, Michael V. Sofroniew
Transected axons fail to regrow in the mature central nervous system. Astrocytic scars are widely regarded as causal in this failure. Here, using three genetically targeted loss-of-function manipulations in adult mice, we show that preventing astrocyte sca ...
Nature Publishing Group2016