Concept

Colony-stimulating factor

Publications associées (33)

Identification of a Novel Wnt Inhibitor

Cancer cells are embedded in a microenvironment composed of stromal cells, such as fibroblasts, endothelial cells, infiltrating immune cells, as well as non-cellular compartments such as the extracellular matrix and secreted soluble factors. For successful ...

EPFL2012

Induction of type I IFNs by intracellular DNA-sensing pathways

Andrea Ablasser

A successful antimicrobial immune response involves the coordinate action of cells and soluble factors, with the cytokine family of type I interferons (IFNs) having a central role. Type I IFNs are not only crucial in conferring immediate antimicrobial, mos ...

2012

ER and PR signaling nodes during mammary gland development

Cathrin Brisken, Tamara Tanos, Lucia Jimenez Rojo

The ovarian hormones estrogen and progesterone orchestrate postnatal mammary gland development and are implicated in breast cancer. Most of our understanding of the molecular mechanisms of estrogen receptor (ER) and progesterone receptor (PR) signaling ste ...

BioMed Central2012

Cell encapsulation technology as a novel strategy for human anti-tumor immunotherapy

Vivianne Padrun, Nicolas Bouche

Granulocyte-macrophage colony-stimulating factor (GM-CSF) as an adjuvant in autologous cell-based anti-tumor immunotherapy has recently been approved for clinical application. To avoid the need for individualized processing of autologous cells, we develope ...

Nature Publishing Group2011

Regulation of macrophage arginase expression and tumor growth by the Ron receptor tyrosine kinase

Michele De Palma, Mario Leonardo Squadrito, Shan Yu

M1 activation of macrophages promotes inflammation and immunity to intracellular pathogens, whereas M2 macrophage activation promotes resolution of inflammation, wound healing, and tumor growth. These divergent phenotypes are characterized, in part, by the ...

2011

Factors determining the spontaneous activation of splenic dendritic cells in culture

Freddy Radtke, Ute Koch, Anne Wilson

Dendritic cells (DCs) serve as a link between the innate and adaptive immune systems. The activation state of DCs is crucial in this role. However, when DCs are isolated from lymphoid tissues, purified and placed in culture they undergo 'spontaneous' activ ...

SAGE Publications2011

Novel determinants of the hematopoietic microenvironment in development and homeostasis

Olaia Maria Naveiras Torres-Quiroga

The promise of regenerative medicine depends on succeeding at generating sufficient amounts of functional, transplantable tissue by reliably differentiating pluripotent stem cells through the paths of ontogeny, or by efficiently expanding adult stem cells ...

Harvard University2009

Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment

Olaia Maria Naveiras Torres-Quiroga

Osteoblasts and endothelium constitute functional niches that support haematopoietic stem cells in mammalian bone marrow. Adult bone marrow also contains adipocytes, the number of which correlates inversely with the haematopoietic activity of the marrow. F ...

2009

The effect of lactose-conjugated silk biomaterials on the development of fibrogenic fibroblasts

Boris Hinz

Surface properties of implanted biomaterials can cause fibrotic tissue reactions by stimulating differentiation of host fibroblasts into contractile myofibroblasts. Silk fibroin (SF) protein has been used as biomaterial in pure and blended form. however, i ...

Elsevier2008

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

Anne Wilson, Sandra Eloise Kjeldsen, Cyrille Dunant, Maike Jaworski

Bone marrow hematopoietic stem cells (HSCs) are crucial to maintain lifelong production of all blood cells. Although HSCs divide infrequently, it is thought that the entire HSC pool turns over every few weeks, suggesting that HSCs regularly enter and exit ...

2008

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