Publications associées à Proline

Novel inhibitors of kallikrein proteases and uses thereof

Christian Heinis, Alessandro Zorzi, Patrick Andreas Gonschorek

The present invention relates to a cyclic inhibitor of a kallikrein protease comprising or consisting of (I) the peptide (X1 (X2)(X3)R(X4)(X5)(X6)(X7)(X8)(X9)(X10)(X11) (Formula (X)), wherein (X1) is present or absent and, is preferably present, and if pre ...

2021

Microhydration of Biomolecules: Revealing the Native Structures by Cold Ion IR Spectroscopy

Andrei Zviagin, Viktoriia Aladinskaia

The native-like structures of protonated glycine and peptide Gly3H+ were elucidated using cold ion IR spectroscopy of these biomolecules hydrated by a controlled number of water molecules. The complexes were generated directly from an aqueous solution usin ...

2021

Transmembrane Prolines Mediate Signal Sensing and Decoding in Bacillus subtilis DesK Histidine Kinase

Matteo Dal Peraro, Luciano Andres Abriata

Environmental awareness is an essential attribute of all organisms. The homeoviscous adaptation system of Bacillus subtilis provides a powerful experimental model for the investigation of stimulus detection and signaling mechanisms at the molecular level. ...

American Society for Microbiology2019

Kinetically Trapped Liquid-State Conformers of a Sodiated Model Peptide Observed in the Gas Phase

Thomas Rizzo, Chiara Masellis, Markus Schneider, Carsten Baldauf

We investigate the peptide AcPheAla(5)Lyar(+), a model system for studying helix formation in the gas phase, in order to fully understand the forces that stabilize the helical structure. In particular, we address the question of whether the local fixation ...

2017

Conformations of prolyl-peptide bonds in the bradykinin 1-5 fragment in solution and in the gas phase

Thomas Rizzo, Antoine Louis Claude Masson, Michael Zachary Kamrath, Liudmila Voronina, Carsten Baldauf

The dynamic nature of intrinsically disordered peptides makes them a challenge to characterize by solution-phase techniques. In order to gain insight into the relation between the disordered state and the environment, we explore the conformational space of ...

Amer Chemical Soc2016

Phage selection of chemically stabilized alpha-helical peptide ligands

Christian Heinis, Pierre Vincent Dessen, Philippe Diderich, Davide Bertoldo, Maola Khan Mohammad Golam

Short alpha-helical peptides stabilized by linkages between constituent amino acids offer an attractive format for ligand development. In recent years, a range of excellent ligands based on stabilized alpha-helices were generated by rational design using a ...

2016

Micrococcin P1-A bactericidal thiopeptide active against Mycobacterium tuberculosis

Stewart Cole, Ruben Hartkoorn, Andrej Benjak

The lack of proper treatment for serious infectious diseases due to the emergence of multidrug resistance reinforces the need for the discovery of novel antibiotics. This is particularly true for tuberculosis (TB) for which 3.7% of new cases and 20% of pre ...

Elsevier2016

Novel inhibitors of the enzyme activated factor xii (fxiia)

Christian Heinis, Jonas Alfred Karl Wilbs, Vanessa Baeriswyl, Simon Jan Middendorp

The present invention relates to a bicyclic inhibitor of the coagulation enzyme activated factor XII (FXIIa) comprising or consisting of the peptide (X1)(X2)(X3)n(X4)(X5)(X6)m(X7)(X9)l(X10)(X11)(X12)(X13)(X14)k(X15)(X16), wherein (X1) is present or absent ...

2016

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Proline

Novel inhibitors of kallikrein proteases and uses thereof

Microhydration of Biomolecules: Revealing the Native Structures by Cold Ion IR Spectroscopy

Transmembrane Prolines Mediate Signal Sensing and Decoding in Bacillus subtilis DesK Histidine Kinase

Kinetically Trapped Liquid-State Conformers of a Sodiated Model Peptide Observed in the Gas Phase

Gas-phase probes of kinetically trapped peptides

Conformations of prolyl-peptide bonds in the bradykinin 1-5 fragment in solution and in the gas phase

Phage selection of chemically stabilized alpha-helical peptide ligands

Development of Stapling Methods by Selective Side Chain Modifications of Bioactive Peptides

Micrococcin P1-A bactericidal thiopeptide active against Mycobacterium tuberculosis

Novel inhibitors of the enzyme activated factor xii (fxiia)

Graph Chatbot

Chattez avec Graph Search

Novel inhibitors of kallikrein proteases and uses thereof

Microhydration of Biomolecules: Revealing the Native Structures by Cold Ion IR Spectroscopy

Transmembrane Prolines Mediate Signal Sensing and Decoding in Bacillus subtilis DesK Histidine Kinase

Kinetically Trapped Liquid-State Conformers of a Sodiated Model Peptide Observed in the Gas Phase

Conformations of prolyl-peptide bonds in the bradykinin 1-5 fragment in solution and in the gas phase

Phage selection of chemically stabilized alpha-helical peptide ligands

Micrococcin P1-A bactericidal thiopeptide active against Mycobacterium tuberculosis

Development of Stapling Methods by Selective Side Chain Modifications of Bioactive Peptides

Gas-phase probes of kinetically trapped peptides

Novel inhibitors of the enzyme activated factor xii (fxiia)