Concept
Hereditary cancer syndrome
Publications associées (204)
Lymphatic function, lymphangiogenesis, and cancer metastasis
The lymphatic system serves as the primary route for the metastasis of many cancers and the extent of lymph node involvement is the most important indicator of tumor aggressiveness. Despite the apparent importance of the lymphatic vessels for tumor dissemi ...
2001Rearrangements of minisatellites in the human telomerase reverse transcriptase gene are not correlated with its expression in colon carcinomas
Telomerase activation is crucial in human carcinogenesis. The limiting component of telomerase, the catalytic subunit (hTERT), is undetectable in normal somatic cells but present in most tumor cells, including the earliest stages of colon carcinoma. The me ...
2001Synthesis of cyclo-β-tripeptides and their biological in vitro evaluation as antiproliferatives against the growth of human cancer cell lines
A number of cyclo-β-tripeptides and their linear precursors were subjected to primary biol. evaluation for cancer-cell growth inhibition (one-dose, three-cell essay), and the five most active ones were then tested in the anti-tumor screen of the National C ...
2001Stability of the fluorescence measurement of Foscan in the normal human oral cavity as an indicator of its content in early cancers of the esophagus and the bronchi
Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger
Photodynamic therapy (PDT) with Foscan (mTHPC) is used to cure early cancers of the esophagus or the tracheobronchial tree. However, fixed PDT parameters (drug dose, light dose, etc.) do not permit an accurate prediction of the tissue damage. Large interpa ...
1999Photodynamic therapy for 101 early cancers of the upper aerodigestive tract, the esophagus, and the bronchi: a single-institution experience
Hubert van den Bergh, Georges Wagnières, Alain Woodtli
Cancer, when detected at an early stage, has a very good probability of being eradicated by surgery or radiotherapy. However, less aggressive treatments also tend to provide high rates of cure without the side effects of radical therapy. We report on the r ...
Hindawi Publishing Corporation1999Time-resolved spectrofluorometer for clinical tissue characterization during endoscopy
Hubert van den Bergh, Georges Wagnières
Time-resolved fluorescence spectroscopy has the potential to provide more information for the detection of early cancer than continuous wave spectroscopy. A new optical fiber-based spectrofluorometer for time-resolved fluorescence spectroscopy of biol. tis ...
American Institute of Physics1999Spectroscopic studies of photobleaching and photoproduct formation of meta(tetrahydroxyphenyl)chlorin (m-THPC) used in photodynamic therapy. The production of singlet oxygen by m-THPC
Hubert van den Bergh, Georges Wagnières
Meta(tetrahydroxyphenyl)chlorin (m-THPC) is a new photosensitizer currently undergoing clin. trials at Lausanne's CHUV hospital for photodynamic therapy (PDT) of early cancer in the upper aerodigestive tract. The illumination of m-THPC with light at 650 nm ...
Elsevier1998Clinical photodynamic therapy for superficial cancer in the esophagus and the bronchi: 514 nm compared with 630 nm light irradiation after sensitization with Photofrin II
Hubert van den Bergh, Georges Wagnières
Photodynamic therapy (PDT) for cancer in the esophagus and bronchi with red (630 nm) light may occasionally lead to wall perforation and fistula. Therefore, the clin. use of a less penetrating wavelength (514 nm) was investigated for the curative treatment ...
1998Clinical imaging fluorescence apparatus for the endoscopic photodetection of early cancers by use of Photofrin II
Hubert van den Bergh, Christian Depeursinge, Georges Wagnières, André Châtelain, André Studzinski
A fluorescence imaging device applied to the detection of early cancer is described. The app. is based on the imaging of laser-induced fluorescence of a dye that localizes in a tumor with a higher concn. than in the surrounding normal tissue after i.v. inj ...
Optical Society of America1997Clinical imaging fluorescence apparatus for the endoscopic photodetection of early cancers by use of Photofrin II
Christian Depeursinge, Georges Wagnières, André Studzinski
A fluorescence imaging device applied to the detection of early cancer is described. The apparatus is based on the imaging of laser-induced fluorescence of a dye that localizes in a tumor with a higher concentration than in the surrounding normal tissue af ...
1997