Concept

Juxtacrine

Publications associées (201)

Notch Signaling - a Booster of Chronic Lymphocytic Leukemia During Initiation and Disease Progression

Chronic lymphocytic leukemia (CLL) is a B cell malignancy and represents the most common leukemia in adults within the Western world. This disease mainly affects the elderly, with a median age of diagnosis over 70. The disease course is highly variable amo ...

EPFL2020

Triggering of a Dll4–Notch1 loop impairs wound healing in diabetes

Freddy Radtke

Diabetic foot ulcerations (DFUs) represent a major medical, social, and economic problem. Therapeutic options are restricted due to a poor understanding of the pathogenic mechanisms. The Notch pathway plays a pivotal role in cell differentiation, prolifera ...

2019

Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell

Steinunn Baekkeskov Hanahan, Chiara Cianciaruso, Petra Catalina Schwalie, Edward Allen Phelps

Pancreatic beta cells synthesize and secrete the neurotransmitter GABA (gamma-aminobutyric acid) as a paracrine and autocrine signal to help regulate hormone secretion and islet homeostasis. Islet GABA release has classically been described as a secretory- ...

2019

Quantitative relationships between SMAD dynamics and target gene activation kinetics in single live cells

Felix Naef, David Michael Suter, Torgil Elias Friman, Onur Tidin

The transduction of extracellular signals through signaling pathways that culminate in a transcriptional response is central to many biological processes. However, quantitative relationships between activities of signaling pathway components and transcript ...

2019

Computational design of G Protein-Coupled Receptor allosteric signal transductions

Patrick Daniel Barth, Dániel Kéri

Membrane receptors sense and transduce extracellular stimuli into intracellular signaling responses but the molecular underpinnings remain poorly understood. We report a computational approach for designing protein allosteric signaling functions. By combin ...

2019

Synaptic proximity enables NMDAR signalling to promote brain metastasis

Graham Knott, Douglas Hanahan, Brian Donal McCabe, Mohammad Sadegh Saghafinia, Inti Zlobec, Iacovos Michael, Qiqun Zeng, Wei Jiao, Giovanni Ciriello, Peng Zhang

Metastasis-the disseminated growth of tumours in distant organs-underlies cancer mortality. Breast-to-brain metastasis (B2BM) is a common and disruptive form of cancer and is prevalent in the aggressive basal-like subtype, but is also found at varying freq ...

2019

Circadian rhythms and proteomics: It's all about posttranslational modifications!

Daniel Alain Dominique Marie Mauvoisin

The circadian clock is a molecular endogenous timekeeping system and allows organisms to adjust their physiology and behavior to the geophysical time. Organized hierarchically, the master clock in the suprachiasmatic nuclei, coordinates peripheral clocks, ...

WILEY2019

Selectively Permeable Double Emulsions

Esther Amstad, Irvine Lian Hao Ong

Natural organisms are made of different types of microcompartments, many of which are enclosed by cell membranes. For these organisms to display a proper function, the microcompartments must be selectively permeable. For example, cell membranes are typical ...

2019

Closed-loop Controlled Brillouin Optical Time-domain Analysis

Luc Thévenaz, Zhisheng Yang

A novel concept to retrieve information in Brillouin distributed fiber sensors is presented, in which the interacting signals are conditioned to track a uniform gain along the fiber, showing 100× faster acquisition at similar accuracy. ...

Optical Society of America2018

Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation

Christoph Merten

How signaling dynamics encode information is a central question in biology. During vertebrate development, dynamic Notch signaling oscillations control segmentation of the presomitic mesoderm (PSM). In mouse embryos, this molecular clock comprises signalin ...

2018

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