Concept

Diversité génétique

Publications associées (186)

Simultaneous preservation of the DNA quality, the community composition and the density of freshwater oligochaetes for the development of genetically based biological indices

Introduction. Oligochaetes are recognized as valuable bioindicators of sediment quality in streams and lakes. The development of an oligochaete index based on the identification of specimens using DNA barcodes requires a method for simultaneously preservin ...

2018

Computational and Statistical analyses of Molecular Evolution and Demography using Large-scale Sequencing Data

Adamantia Kapopoulou

Evolution can be described as the change of allele frequencies over time. Four forces - mutation, migration, genetic drift, and selection, drive this change. The aim of my thesis was to accurately estimate and differentiate the parameters governing each of ...

EPFL2018

Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells

Jacques Fellay

The highly polymorphic human leukocyte antigen (HLA) locus encodes cell surface proteins that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner, diversifying allele-specific effects beyond peptide-binding preference. Ana ...

2018

Genetic determinants of healthy human immune variance: from humoral response to microbiome diversity

Petar Scepanovic

Identifying the drivers of the observed interindividual variability of the human immune system is crucial to our understanding of infectious and immune-mediated diseases. The contribution of genetic and non-genetic factors to immunological differences betw ...

EPFL2018

Visual masking deficits in schizophrenia: A view into the genetics of the disease through an endophenotype

Michael Herzog, Jacques Fellay, Maya Roinishvili, Flavia Aurelia Shoko Hodel

Schizophrenia is a chronic disorder determined by a complex mix of genetic and environmental factors. To better understand the contributions of human genetic variation to schizophrenia, we performed a genome-wide association study of a validated endophenot ...

2018

The phenotypic impact of naturally occurring genetic and molecular mitochondrial variation in a Drosophila Genetic Reference Population

Roel Paulus Josephus Bevers

Genome-wide association (GWA) studies aim to dissect the relationship between genotype and phenotype. So far, the focus has been on nuclear genetic determinants as variation in the mitochondrial genome is often low in the study cohorts. Despite this observ ...

EPFL2018

Environmental heterogeneity promotes spatial resilience of phototrophic biofilms in streambeds

Andrea Rinaldo, Tom Ian Battin, Hannes Markus Peter, Enrico Bertuzzo, Mário Jorge Rodrigues Pereira Da Franca, Carmelo Juez Jiménez

The loss of environmental heterogeneity threatens biodiversity and ecosystem functioning. It is therefore important to understand the relationship between environmental heterogeneity and spatial resilience as the capacity of ecological communities embedded ...

2018

Influence of lateral embayments on suspended sediment transport under unsteady flow conditions

Anton Schleiss, Mário Jorge Rodrigues Pereira Da Franca, Carmelo Juez Jiménez, Matthias Thalmann

Local widening in a channelized river is a common practice in restoration projects. The lateral embayments built for this purpose in the river banks are partially filled up by fine sediments. This allows the formation of aquatic habitats with hydraulic and ...

2018

GenMon-CH : a Web-GIS application for the monitoring of Farm Animal Genetic Resources (FAnGR) in Switzerland

Stéphane Joost

Since the initation of the Global plan of action for Farm Animal Genetic Resources (FAnGR) in 2007, individual member countries, including Switzerland, should have started a monitoring program. In this context, we developed GenMon-CH, funded by the Federal ...

2017

Cloning of CHO Cells, Productivity and Genetic Stability-A Discussion

Florian Maria Wurm

While many perceive mammalian cell culture-based manufacturing for biopharmaceuticals an established technology, numerous open questions remain to be solved. Genetic diversity and mutation rates in CHO cells have been underestimated since progeny of a clon ...

MDPI2017

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