Scientific literature

Résumé

Scientific literature comprises academic papers that report original empirical and theoretical work in the natural and social sciences. Within a field of research, relevant papers are often referred to as "the literature". Academic publishing is the process of contributing the results of one's research into the literature, which often requires a peer-review process. Original scientific research published for the first time in scientific journals is called the primary literature. Patents and technical reports, for minor research results and engineering and design work (including computer software), can also be considered primary literature. Secondary sources include review articles (which summarize the findings of published studies to highlight advances and new lines of research) and books (for large projects or broad arguments, including compilations of articles). Tertiary sources might include encyclopedias and similar works intended for broad public consumption. Types of

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https://en.wikipedia.org/wiki/Scientific_literature

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Cours associés (41)

Provide the conceptual, technical and methodological understanding of measuring and evaluating the production/consumption decisions on the environmental, social and economic performance of products and services over their life cycle.

Le but du cours de Physique générale est de donner à l'étudiant les notions de base nécessaires à la compréhension des phénomènes physiques. L'objectif est atteint lorsque l'étudiant est capable de prévoir quantitativement les conséquences de ces phénomènes avec des outils théoriques appropriés

Students are lead to understand selected concepts in cell and developmental biology, primarily through the analysis of scientific literature, and then to apply these concepts to the design and execution of a group project in the Gönczy or Oates laboratory.

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Preparation and Analysis of Bacteria Surface-Modified with Polymer Nanoparticles

Lisa Patricia Elisabeth Bader

Cell-based drug carriers present an interesting approach to improve the targeted delivery of therapeutic drugs in vivo. Specifically, bacterial cells possess interesting properties such as motility and sensing that allow some strains to selectively target tumor areas. Immobilization of abiotic materials on the cell surface of such bacterial cells can therefore enable the delivery of therapeutic compounds at the desired location. The work presented in this thesis explores the fabrication and characterization of bacteria-nanoparticle biohybrids as potential carriers for drug delivery applications.Chapter 1 presents a review of the scientific literature that covers the different approaches to immobilize abiotic materials on the surface of bacteria. It highlights the advantages of using cells as carriers for the transport of therapeutics. An effective drug delivery agent should present great motility, viability, biodistribution and biocompatibility with human cells. Examples of various chemical approaches to surface-modify bacteria are presented. Chapter 2 systematically explores the immobilization of polystyrene nanoparticles on the surface of Escherichia coli (E. coli) and Salmonella typhimurium (Salmonella) cells. We compared the nanoparticle immobilization using four different conjugations strategies (electrostatic, covalent and ligand-ligand) and characterized the bio-hybrids systems using flow cytometry and confocal microscopy. Two different microscopy techniques were used: the first was based on 3D-reconstruction of z-stacks of single bacterium to investigate position of nanoparticles on the membrane; the second allowed for a large screening of bacteria followed by image processing determining the area of bacteria covered by nanoparticles. We observed that the efficiency of the surface modification is correlated to the initial nanoparticle/cell ratio and that non-covalent strategies allowed for increased number of biohybrids formed and nanoparticle attached. This study provides an overview of the variety of conjugation strategies (and their conjugation efficiencies) available for fabricating nanoparticle-decorated bacteria and presents us an opportunity to better understand and design bacteria-based target-specific drug delivery systems.Chapter 3 presents the characterization of the previously developed bacteria-nanoparticle biohybrids as potential carriers for nanoparticle transport. The viability of the various conjugates was determined by flow cytometry indicating a decrease in cell viability with increasing numbers of nanoparticles immobilized on the membrane. The motility was studied to investigate the impact of nanoparticle attachment on the bacterial velocity as well as the capacity to transport the cargo. Bacteria were able to transport nanoparticles when prepared with low ratios of nanoparticle/cell.

EPFL2022

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The drastic shift towards digital communication in our mediasphere has caused a profound change in the production and consumption of information, which in turn has substantial implications on the social and political landscape. Misinformation, as a side effect of mass information diffusion, has become a fundamental problem for governments, platforms, and the general public in light of critical events such as elections, pandemics, and wars. In this thesis, we focus on the problem of online scientific misinformation. As a starting point, we survey the evolution of misinformation and present the main characteristics and approaches against it, framing the high-level positioning of this thesis with respect to related literature. Then, we discuss three major scientific contributions of this thesis: our methods for combating claim-based, article-based, and source-based scientific misinformation.For combating claim-based scientific misinformation, we introduce SciClops, a method for detecting and contextualizing scientific claims for assisting manual fact-checking. Our method involves three steps: (1) extracting scientific claims using a domain-specific, fine-tuned transformer model, (2) clustering similar claims together with related scientific literature using a method that exploits their content and the connections among them, and (3) highlighting check-worthy claims broadcasted by popular yet unreliable sources. Our experiments show that SciClops effectively assists non-expert fact-checkers in verifying complex scientific claims, facilitating them to outperform commercial fact-checking systems.For combating article-based scientific misinformation, we introduce SciLens, a method for evaluating the quality of scientific news articles. Our method involves a series of quality indicators for news articles that derive from: (1) their content, including the use of attributed quotes, (2) their scientific context, including their semantic similarity and web proximity to the scientific literature, and (3) their social context, including their social media reach and stance. Our experiments show that these indicators help non-experts evaluate the quality of articles more accurately compared to non-experts that do not have access to these indicators. Moreover, SciLens can also produce completely automated quality scores for articles, which agree more with expert evaluators than manual evaluations done by non-experts.For combating source-based scientific misinformation, we introduce SciLander, a method for learning representations of news sources reporting on scientific topics. Our method involves heterogeneous source indicators that capture: (1) the copying of news stories between sources, (2) the semantic shift of terms across sources, (3) the usage of jargon, and (4) the stance towards specific citations. SciLander uses these indicators as signals of source agreement to train unsupervised source embeddings. Our experiments show that the learned source representations outperform state-of-the-art baselines on the task of news veracity classification while encoding information about the reliability, political leaning, and partisanship bias of these sources.In the last part of this thesis, we introduce NewsTeller, a real-time news analytics platform that runs operationally, handling daily thousands of news articles, social media reactions, and references.

EPFL2022

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Tunnel in urban site - Lausanne Metro m3 Section Casernes – Blécherette

Loïc Bonny

The objective of this scientific paper is to present the m3 metro project, in particular the Casernes-Blécherette section. The article is a summary of the final project development based on the technical report [1]. It includes the geological and hydrogeological context, the general concept of the structures, the execution methods, the inventory of constraints, the dimensioning of the structures and its elements, the typical excavation profiles and the normal profiles of the tunnels, the excavation and support profiles and the normal profiles of the stations, as well as the installation and logistics of the construction site. The urban context and the requirement of the client to maintain at least one traffic lane in each direction impose a top-down construction of the stations: This method consists in retaining walls in secant piles and a cover slab before excavation of the station. The tunnel will be built as a cutand- cover, near the stations where the ground cover is not sufficient, and as an underground tunnel.

2021

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Preparation and Analysis of Bacteria Surface-Modified with Polymer Nanoparticles

Lisa Patricia Elisabeth Bader

EPFL2022