Publications associées à Super-famille de protéines

The evolution of multiple active site configurations in a designed enzyme

Developments in computational chemistry, bioinformatics, and laboratory evolution have facilitated the de novo design and catalytic optimization of enzymes. Besides creating useful catalysts, the generation and iterative improvement of designed enzymes can ...

NATURE PUBLISHING GROUP2018

A microfluidic array for high-content screening at whole-organism resolution

Johan Auwerx, Martinus Gijs, Matteo Cornaglia, Laurent Mouchiroud, Daniel Migliozzi

A main step for the development and the validation of medical drugs is the screening on whole organisms, which gives the systemic information that is missing when using cellular models. Among the organisms of choice, Caenorhabditis elegans is a soil worm w ...

SPIE-INT SOC OPTICAL ENGINEERING2018

Evaluating the similarity of biochemical reactions and its uses for mapping novel reactions to protein sequences

Vassily Hatzimanikatis, Homa Mohammadi Peyhani, Noushin Hadadi

A key challenge in metabolic engineering is to design novel or to improve existing biosynthetic pathways that lead to the cellular production of a given industrial or pharmaceutical compound. In many cases, the required enzymatic reactions for the biosynth ...

2017

Versatile Tool for the Analysis of Metal-Protein Interactions Reveals the Promiscuity of Metallodrug-Protein Interactions

Paul Joseph Dyson, Laure Menin, Luc Patiny

Metallodrug protein interactions contribute to their therapeutic effect (even when DNA is the dominant target), side-effects and are implicit in drug resistance. Here, we provide mass spectrometric-based evidence to show that metallodrug interactions with ...

2017

Membrane scission driven by the PROPPIN Atg18

Hilal Lashuel, Bruno Claude Daniel Fauvet, Andreas Mayer

Sorting, transport, and autophagic degradation of proteins in endosomes and lysosomes, as well as the division of these organelles, depend on scission of membrane-bound tubulo-vesicular carriers. How scission occurs is poorly understood, but family protein ...

Nature Publishing Group2017

New Techniques for Ancient Proteins: Direct Coupling Analysis Applied on Proteins Involved in Iron Sulfur Cluster Biogenesis

Paolo De Los Rios, Duccio Malinverni

Direct coupling analysis (DCA) is a powerful statistical inference tool used to study protein evolution. It was introduced to predict protein folds and protein-protein interactions, and has also been applied to the prediction of entire interactomes. Here, ...

2017

Design of novel enzyme-catalyzed reactions linked to protein sequences for finding enzyme engineering targets

Vassily Hatzimanikatis, Jasmin Maria Hafner, Homa Mohammadi Peyhani, Noushin Hadadi

A key challenge in metabolic engineering is to find and to improve biosynthetic pathways that lead to the cellular production of a given industrial, pharmaceutical or specialty chemical compound. In many cases, the enzymatic reactions required for bio-prod ...

2017

Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation

Hilal Lashuel, Lara Petricca, Anass Chiki, Sean Michael Deguire

Posttranslational modifications can have profound effects on the biological and biophysical properties of proteins associated with misfolding and aggregation. However, their detection and quantification in clinical samples and an understanding of the mecha ...

2017

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Super-famille de protéines

The evolution of multiple active site configurations in a designed enzyme

Enhanced Student Learning in Proteomics - an Interactive Tool Support for Teaching Workflows

A microfluidic array for high-content screening at whole-organism resolution

Clustering on Membranes: Fluctuations and More

Evaluating the similarity of biochemical reactions and its uses for mapping novel reactions to protein sequences

Versatile Tool for the Analysis of Metal-Protein Interactions Reveals the Promiscuity of Metallodrug-Protein Interactions

Membrane scission driven by the PROPPIN Atg18

New Techniques for Ancient Proteins: Direct Coupling Analysis Applied on Proteins Involved in Iron Sulfur Cluster Biogenesis

Design of novel enzyme-catalyzed reactions linked to protein sequences for finding enzyme engineering targets

Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation

Graph Chatbot

Chattez avec Graph Search

Enhanced Student Learning in Proteomics - an Interactive Tool Support for Teaching Workflows

Clustering on Membranes: Fluctuations and More

A microfluidic array for high-content screening at whole-organism resolution

Design of novel enzyme-catalyzed reactions linked to protein sequences for finding enzyme engineering targets

Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation

Versatile Tool for the Analysis of Metal-Protein Interactions Reveals the Promiscuity of Metallodrug-Protein Interactions

Evaluating the similarity of biochemical reactions and its uses for mapping novel reactions to protein sequences

The evolution of multiple active site configurations in a designed enzyme

Membrane scission driven by the PROPPIN Atg18

New Techniques for Ancient Proteins: Direct Coupling Analysis Applied on Proteins Involved in Iron Sulfur Cluster Biogenesis