Concept

Epigenetic clock

Publications associées (55)

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by alpha-synuclein overexpression

Grégoire Courtine, Laetitia Danielle Philippine Baud, Isabel Laura Vollenweider

Introduction: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons as well as the presence of proteinaceous inclusions named Lewy bodies. alpha synuclein (alpha-syn) is a major constituent o ...

Biomed Central Ltd2015

Multi-factorial models of a carbon fibre/epoxy composite subjected to accelerated environmental ageing

Joël Cugnoni, Enrique René Guzman Solares

Among materials being introduced in the aerospace industry, the carbon fibre reinforced plastics (CFRP) have a place of privilege because of their exceptional stiffness-to-mass ratio. However, the polymer-based matrix is vulnerable to damages by environmen ...

Elsevier2014

Reprint of: Musculoskeletal system in the old age and the demand for healthy ageing biomarkers

Martin Kussmann, Sofia Moco, Sebastiano Collino

Population ageing has emerged as a major demographic trend worldwide due to improved health and longevity. This global ageing phenomenon will have a major impact on health-care systems worldwide due to increased morbidity and greater needs for hospitalizat ...

Elsevier Ireland Ltd2014

Hepatotoxicity induced by neonatal exposure to diethylstilbestrol is maintained throughout adulthood via the nuclear receptor SHP

Kristina Schoonjans

Background: Liver physiology is sensitive to estrogens, which suggests that the liver might be a target of estrogenic endocrine disrupters (EED). However, the long-term consequences of neonatal exposure to EED on liver physiology have rarely been studied. ...

Informa Healthcare2014

Interplay of TRIM28 and DNA methylation in controlling human endogenous retroelements

Didier Trono, Priscilla Turelli, Julien Léonard Duc, Charlène Mireille Raymonde Raclot, Adamantia Kapopoulou, Flavia Marzetta

Reverse transcription-derived sequences account for at least half of the human genome. Although these retroelements are formidable motors of evolution, they can occasionally cause disease, and accordingly are inactivated during early embryogenesis through ...

Cold Spring Harbor Lab Press, Publications Dept2014

Survivability of integrated PVDF film sensors to accelerated ageing conditions in aeronautical/aerospace structures

Alain Schorderet, Joël Cugnoni, Enrique René Guzman Solares

This work validates the use of integrated polyvinylidene fluoride (PVDF) film sensors for dynamic testing, even after being subjected to UV-thermo-hygro-mechanical accelerated ageing conditions. The verification of PVDF sensors' survivability in these envi ...

Institute of Physics2013

Aging biomarkers

Johan Auwerx, Richardus Houtkooper

The present invention relates to novel biomarkers for aging and healthspan, methods and uses thereof, in particular, for determining the biological age of a subject and/or preventing or delaying aging process in a subject, and kits for use in said methods. ...

2013

Musculoskeletal system in the old age and the demand for healthy ageing biomarkers

Martin Kussmann, Sofia Moco, Sebastiano Collino

Elsevier Ireland Ltd2013

Histone acetylation: molecular mnemonics on the chromatin

Johannes Gräff

Long-lasting memories require specific gene expression programmes that are, in part, orchestrated by epigenetic mechanisms. Of the epigenetic modifications identified in cognitive processes, histone acetylation has spurred considerable interest. Whereas in ...

2013

Foil-to-foil interconnection of capacitive humidity sensors using electrically conductive adhesives

Nico de Rooij, Danick Briand

The present study presents the development and comparison of two foil-to-foil lamination and interconnection methods of foil-based capacitive humidity sensors. The first method uses confined anisotropic conductive adhesive (ICA) in laser ablated vias throu ...

2013

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