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Publications associées (7)

Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors

Patrick Descombes, Sylviane Métairon, Sonia Karaz, Omid Mashinchian, Guillaume Jacot, Laura Lukjanenko, Federico Sizzano, Sara Ancel

Research on age-related regenerative failure of skeletal muscle has extensively focused on the phenotypes of muscle stem cells (MuSCs). In contrast, the impact of aging on regulatory cells in the MuSC niche remains largely unexplored. Here, we demonstrate ...

CELL PRESS2019

Novel interventions to recover the regenerative capacity of aged skeletal muscle by targeting the interactions in the stem cell niche

Laura Lukjanenko

The remarkable ability of skeletal muscle to regenerate upon injury is conferred by tissue-resident stem cells called satellite cells. With age, the regenerative capacity of muscle stem cells (MuSCs) dramatically declines. Developing strategies to enhance ...

EPFL2016

Muscle synergies and spinal maps are sensitive to the asymmetry induced by a unilateral stroke

Silvestro Micera, Martina Coscia

Background: Previous studies have shown that a cerebrovascular accident disrupts the coordinated control of leg muscles during locomotion inducing asymmetric gait patterns. However, the ability of muscle synergies and spinal maps to reflect the redistribut ...

Biomed Central Ltd2015

Undirected compensatory plasticity contributes to neuronal dysfunction after severe spinal cord injury

Grégoire Courtine, Quentin Barraud, Pavel Musienko, Rubia van den Brand, Lucia Florinda Friedli Wittler, Janine Beauparlant

Severe spinal cord injury in humans leads to a progressive neuronal dysfunction in the chronic stage of the injury. This dysfunction is characterized by premature exhaustion of muscle activity during assisted locomotion, which is associated with the emerge ...

Oxford University Press2013

Modulation of multisegmental monosynaptic responses in a variety of leg muscles during walking and running in humans

Grégoire Courtine

Motor responses evoked by stimulating the spinal cord percutaneously between the T11 and T12 spinous processes were studied in eight human subjects during walking and running. Stimulation elicited responses bilaterally in the biceps femoris, vastus lateral ...

Wiley-Blackwell2007

Force and torque vectors at the foot generated by surface electrical stimulation of leg muscles

Reymond Clavel, Patrick Métrailler, Carl Schmitt

MotionMakerTM is a robotic system that employs functional electrical stimulation (FES) of leg muscles to allow subjects with complete or partial paralysis of the legs to perform exercises. To achieve the greatest benefit from exercise muscles should do wor ...

2006

closed loop electrical muscle stimulation in spinal cord injured rehabilitation

Reymond Clavel, Patrick Métrailler

The effect of motor training using closed loop controlled Functional Electrical Stimulation (FES) on motor performance was studied in 5 spinal cord injured (SCI) volunteers. The subjects trained 2 to 3 times a week during 2 months on a newly developed reha ...

2006

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