Concept
Signalisation cellulaire
Publications associées (1 000)
Primary data for "A role for the carbon source of the cell and protein kinase A in regulating the S. pombe septation initiation network"
Viesturs Simanis, Andrea Krapp, Bastien Mangeat, Özge Uysal Özdemir
The Septation Initiation Network (SIN) is a conserved signal transduction network, which is important for cytokinesis in S. pombe. The SIN component Etd1p is required for association of some SIN proteins with the spindle pole body (SPB) during anaphase and ...
EPFL Infoscience2024A role for the carbon source of the cell and protein kinase A in regulating the S. pombe septation initiation network
Viesturs Simanis, Andrea Krapp, Bastien Mangeat, Özge Uysal Özdemir
The septation initiation network (SIN) is a conserved signal transduction network, which is important for cytokinesis in Schizosaccharomyces pombe. The SIN component Etd1p is required for association of some SIN proteins with the spindle pole body (SPB) du ...
2024Computational drug development for membrane protein targets
Pierre Vogel, Henning Paul-Julius Stahlberg, Dongchun Ni, Babatunde Edukpe Ekundayo, Shuguang Yuan
The application of computational biology in drug development for membrane protein targets has experienced a boost from recent developments in deep learning-driven structure prediction, increased speed and resolution of structure elucidation, machine learni ...
2024Engineering hydrogel microenvironments for epithelial organoid culture
Organoids, miniature tissues generated from self-organizing stem cells within three-dimensional (3D) extracellular matrices (ECM), have opened up exciting possibilities for in vitro studies of complex physiological processes. A key factor in the success of ...
EPFL2024Ultraviolet Superradiance from Mega-Networks of Tryptophan in Biological Architectures
Majed Chergui, Katrin Elisabeth Oberhofer
Networks of tryptophan (Trp)& horbar;an aromatic amino acid with strong fluorescence response & horbar;are ubiquitous in biological systems, forming diverse architectures in transmembrane proteins, cytoskeletal filaments, subneuronal elements, photorecepto ...
Amer Chemical Soc2024The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation
Genes implicated in translation control have been associated with autism spectrum disorders (ASDs). However, some important genetic causes of autism, including the 16p11.2 microdeletion, bear no obvious connection to translation. Here, we use proteomics, g ...
Amer Assoc Advancement Science2024Cold stress-induced autophagy and apoptosis disorders are mainly mediated by AMPK/PPAR/PI3K/AKT/mTOR pathways
Under cold stress, the processes of autophagy, apoptosis and energy metabolism are pivotal for sustaining energy and tissue balance. However, the molecular regulatory mechanisms and interactions underlying these processes are still largely unknown. In this ...
Amsterdam2024From Sequence to Dynamics to Function: Computational Design of Allostery and Ligand Selectivity in G-Protein Coupled Receptors
The phenomenon of allostery, a general property in proteins that has been heralded as "the second secret of life" remains elusive to our understanding and even more challenging to incorporate into protein design. One example of allosteric proteins with gre ...
EPFL2024Multimodal transcriptomic atlases of mouse spinal cord injury
A spinal cord injury (SCI) triggers a cascade of molecular and cellular responses involving inflammatory cell infiltration and cytokine release, apoptosis, demyelination, excitotoxicity, ischemia, and the formation of a fibrotic scar surrounded by an astro ...
EPFL2024S-acylation and lipid exchange at the ER-Golgi membrane contact sites regulate pathogen entry in human cells
Cells have evolved endocytic pathways to internalize different molecules, to regulate intra-cellular communication and their interaction with external environment. Pathogens have co-evolved with cells to exploit these processes for infections. In particula ...
EPFL2024