Publications associées à Folding@home

UDP-glucose:glycoprotein glucosyltransferase (UGGT1) promotes substrate solubility in the endoplasmic reticulum

Protein folding in the endoplasmic reticulum (ER) is error prone, and ER quality control (ERQC) processes ensure that only correctly folded proteins are exported from the ER. Glycoproteins can be retained in the ER by ERQC, and this retention contributes t ...

Amer Soc Cell Biology2013

Two Misfolding Routes for the Prion Protein around pH 4.5

Ursula Röthlisberger, Ivano Tavernelli

Using molecular dynamics simulations, we show that the prion protein (PrP) exhibits a dual behavior, with two possible transition routes, upon protonation of H187 around pH 4.5, which mimics specific conditions encountered in endosomes. Our results suggest ...

Public Library Science2013

Understanding NVIDIA GPGPU Hardware

Ogier Philippe Maitre

This chapter presents NVIDIA general purpose graphical processing unit (GPGPU) architecture, by detailing both hardware and software concepts. The evolution of GPGPUs from the beginning to the most modern GPGPUs is presented in order to illustrate the tren ...

Springer Berlin Heidelber2013

Chemical strategies for controlling protein folding and elucidating the molecular mechanisms of amyloid formation and toxicity

Hilal Lashuel, Bruno Claude Daniel Fauvet, Loay Awad, Mirva Hejjaoui

It has been more than a century since the first evidence linking the process of amyloid formation to the pathogenesis of Alzheimer's disease. During the last three decades in particular, increasing evidence from various sources (pathology, genetics, cell c ...

Elsevier2012

Reoptimized interaction parameters for the peptide-backbone model compound N-methylacetamide in the GROMOS force field: Influence on the folding properties of two beta-peptides in methanol

Wei Huang, Bruno Araujo Cautiero Horta

Considering N-methylacetamide (NMA) as a model compound, new interaction parameters are developed for the amide function in the GROMOS force field that are compatible with the recently derived 53A6OXY parameter set for oxygen-containing chemical functions. ...

Wiley-Blackwell2012

Buckling-induced encapsulation of structured elastic shells under pressure

Pedro Miguel Nunes Pereira de Almeida Reis

We introduce a class of continuum shell structures, the Buckliball, which undergoes a structural transformation induced by buckling under pressure loading. The geometry of the Buckliball comprises a spherical shell patterned with a regular array of circula ...

2012

Practicality and time complexity of a sparsified RNA folding algorithm

Philipp Bucher, Slavica Dimitrieva Janeva

Commonly used RNA folding programs compute the minimum free energy structure of a sequence under the pseudoknot exclusion constraint. They are based on Zuker's algorithm which runs in time O(n^3). Recently, it has been claimed that RNA folding can be achie ...

2012

First-order coil-globule transition driven by vibrational entropy

Paolo De Los Rios, Francesco Piazza, Carlo Maffi

By shifting the balance between conformational entropy and internal energy, polymers modify their shape under external stimuli, such as changes in temperature. Prominent among such transformations is the coil-globule transition, whereby a polymer can switc ...

Nature Publishing Group2012

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Folding@home

UDP-glucose:glycoprotein glucosyltransferase (UGGT1) promotes substrate solubility in the endoplasmic reticulum

Mapping the Native Conformational Ensemble of Proteins from a Combination of Simulations and Experiments: New Insight into the src-SH3 Domain

Two Misfolding Routes for the Prion Protein around pH 4.5

Understanding NVIDIA GPGPU Hardware

Chemical strategies for controlling protein folding and elucidating the molecular mechanisms of amyloid formation and toxicity

Reoptimized interaction parameters for the peptide-backbone model compound N-methylacetamide in the GROMOS force field: Influence on the folding properties of two beta-peptides in methanol

Buckling-induced encapsulation of structured elastic shells under pressure

Practicality and time complexity of a sparsified RNA folding algorithm

First-order coil-globule transition driven by vibrational entropy

Multidimensional View of Amyloid Fibril Nucleation in Atomistic Detail

Graph Chatbot

Chattez avec Graph Search

Understanding NVIDIA GPGPU Hardware

Chemical strategies for controlling protein folding and elucidating the molecular mechanisms of amyloid formation and toxicity

Reoptimized interaction parameters for the peptide-backbone model compound N-methylacetamide in the GROMOS force field: Influence on the folding properties of two beta-peptides in methanol

Buckling-induced encapsulation of structured elastic shells under pressure

Multidimensional View of Amyloid Fibril Nucleation in Atomistic Detail

Practicality and time complexity of a sparsified RNA folding algorithm

Two Misfolding Routes for the Prion Protein around pH 4.5

Mapping the Native Conformational Ensemble of Proteins from a Combination of Simulations and Experiments: New Insight into the src-SH3 Domain

First-order coil-globule transition driven by vibrational entropy

UDP-glucose:glycoprotein glucosyltransferase (UGGT1) promotes substrate solubility in the endoplasmic reticulum