Concept
Cholestase intrahépatique familiale progressive à activité gamma-glutamyl-transférase basse
Publications associées (15)
Maternal glucose homeostasis is impaired in mouse models of gestational cholestasis
Women with intrahepatic cholestasis of pregnancy (ICP), a disorder characterised by raised serum bile acids, are at increased risk of developing gestational diabetes mellitus and have impaired glucose tolerance whilst cholestatic. FXR and TGR5 are modulato ...
NATURE PUBLISHING GROUP2020Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
Kristina Schoonjans, Alessia Perino
The systemic expression of the bile acid (BA) sensor farnesoid X receptor (FXR) has led to promising new therapies targeting cholesterol metabolism, triglyceride production, hepatic steatosis and biliary cholestasis. In contrast to systemic therapy, bile a ...
Nature Publishing Group2015Raised hepatic bile acid concentrations during pregnancy in mice are associated with reduced farnesoid X receptor function
Pregnancy alters bile acid homeostasis and can unmask cholestatic disease in genetically predisposed but otherwise asymptomatic individuals. In this report, we show that normal pregnant mice have raised hepatic bile acid levels in the presence of procholes ...
2010