Concept

Tissu adipeux

Publications associées (358)

Transgenic mice reveal novel activities of growth hormone in wound repair, angiogenesis, and myofibroblast differentiation

An increasing number of patients are being treated with growth hormone (GH) for the enhancement of body growth but also as an anti-aging strategy. However, the side effects of GH have been poorly defined. In this study we determined the effect of GH on wou ...

American Society for Biochemistry and Molecular Biology2004

Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice

Johan Auwerx

Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor, which controls adipocyte differentiation. We targeted with homologous recombination the PPAR gamma 2-specific exon B, resulting in a white adipose tissue knockdown of PPAR ...

2003

A functional polymorphism in a STAT5B site of the human PPAR gamma 3 gene promoter affects height and lipid metabolism in a French population

Johan Auwerx

OBJECTIVE: The peroxisome proliferator-activated receptor-gamma (PPARgamma) plays a role in adipocyte differentiation and insulin sensitization. It has been shown that genetic variation in the PPARgamma gene alters body weight control, lipid and insulin ho ...

2003

SRC-1 and TIF2 control energy balance between white and brown adipose tissues

Johan Auwerx

We have explored the effects of two members of the p160 coregulator family on energy homeostasis. TIF2-/- mice are protected against obesity and display enhanced adaptive thermogenesis, whereas SRC-1-/- mice are prone to obesity due to reduced energy expen ...

2003

Repair of bone defects using synthetic mimetics of collagenous extracellular matrices

Matthias Lütolf, Jeffrey Alan Hubbell, Randoald Müller

We have engineered synthetic poly(ethylene glycol) (PEG)-based hydrogels as cell-ingrowth matrices for in situ bone regeneration. These networks contain a combination of pendant oligopeptide ligands for cell adhesion (RGDSP) and substrates for matrix metal ...

2003

Leptin: cutting the fat off the bone

Johan Auwerx

CONTEXT: Leptin was initially proposed to be the antiobesity hormone. Now it is realised that leptin is more a signal molecule that communicates nutritional status to the brain, and that it is involved in bone formation by having an antiosteogenic action. ...

2003

Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics

Matthias Lütolf, Jeffrey Alan Hubbell

Synthetic hydrogels have been molecularly engineered to mimic the invasive characteristics of native provisional extracellular matrixes: a combination of integrin-binding sites and substrates for matrix metalloproteinases (MMP) was required to render the n ...

2003

Prevention of the initial host immuno-inflammatory response determines the long-term survival of encapsulated myoblasts genetically engineered for erythropoietin delivery

Patrick Aebischer, Bernard Schneider

The present study investigates the respective roles of both the host immune response and the metabolic requirements in determining the long-term survival of erythropoietin-secreting myoblasts within encapsulating polymer membranes. Hollow-fiber capsules lo ...

2003

beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system

Thomas Muller

beta-Catenin is an essential component of the canonical Wnt signaling system that controls decisive steps in development. We employed here two conditional beta-catenin mutant alleles to alter beta-catenin signaling in the central nervous system of mice: on ...

2003

Biphasic constitutive laws for biological interface evolution

Dominique Pioletti, Lalaonirina Rakotomanana Ravelonarivo, Philippe Büchler

A model of tissue differentiation at the bone-implant interface is proposed. The basic hypothesis of the model is that the mechanical environment determines the tissue differentiation. The stimulus chosen is related to the bone-implant micromotions. Equati ...

2003

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