Concept
Tumour heterogeneity
Publications associées (116)
Exploring the role of cGAS-STING-mediated inflammation in age-associated neurodegeneration and antitumor immunity
Inflammation stands as a dynamic and intricate biological process, promoting vital defence mechanisms against harmful stimuli, including infections and injuries, to drive pathogen clearance and healing. On one hand, these responses can manifest acutely and ...
EPFL2024Mutation-Attention (MuAt): deep representation learning of somatic mutations for tumour typing and subtyping
Background: Cancer genome sequencing enables accurate classification of tumours and tumour subtypes. However, prediction performance is still limited using exome-only sequencing and for tumour types with low somatic mutation burden such as many paediatri ...
2023Whole-genome doubling drives oncogenic loss of chromatin segregation
Elisa Oricchio, Daniele Tavernari, Natalya Katanayeva, Ruxandra-Andreea Lambuta, Juan Diaz Miyar, Giovanni Ciriello
Whole-genome doubling (WGD) is a recurrent event in human cancers and it promotes chromosomal instability and acquisition of aneuploidies(1-8). However, the three-dimensional organization of chromatin in WGD cells and its contribution to oncogenic phenotyp ...
NATURE PORTFOLIO2023Whole genome doubling promotes tumorigenesis through loss of chromatin segregation and compartment repositioning
Whole genome doubling (WGD) events are drivers of genetic innovation across vertebrate evolution. While generally detrimental to mammalian organisms, WGDs are crucial in the development of various plants and fungi, as well as for the terminal differentiati ...
EPFL2023Everolimus for Children With Recurrent or Progressive Low-Grade Glioma: Results From the Phase II PNOC001 Trial
PURPOSE The PNOC001 phase II single-arm trial sought to estimate progression-free survival (PFS) associated with everolimus therapy for progressive/recurrent pediatric low-grade glioma (pLGG) on the basis of phosphatidylinositol 3-kinase (PI3K)/AKT/mammali ...
2023Combined use of intraoperative MRI and awake tailored microsurgical resection to respect functional neural networks: preliminary experience
INTRODUCTION: The combined use of intraoperative MRI and awake surgery is a tailored microsurgical resection to respect functional neural networks (mainly the language and motor ones). Intraoperative MRI has been classically considered to increase the exte ...
2023Stereotactic Radiosurgery for Benign Cavernous Sinus Meningiomas: A Multicentre Study and Review of the Literature
Simple Summary Meningiomas are the most common tumours of the central nervous system (CNS). Despite their benign histology, proximity to critical neurovascular structures may lead to significant morbidity with tumour growth. This is the case for cavernous ...
MDPI2022Technological and computational advances driving high-throughput oncology
Christoph Merten, Alexis Louis Autour, Xiaoli Ma, Leonie Kolmar, Blandine Anne Catherine Vergier
Engineering and computational advances have opened many new avenues in cancer research, particularly when being exploited in interdisciplinary approaches. For example, the combination of microfluidics, novel sequencing technologies, and computational analy ...
ELSEVIER SCIENCE LONDON2022Non-genomic activation of the AKT-mTOR pathway by the mitochondrial stress response in thyroid cancer
Johan Auwerx, Kristina Schoonjans, Dongryeol Ryu
Cancer progression is associated with metabolic reprogramming and causes significant intracellular stress; however, the mechanisms that link cellular stress and growth signalling are not fully understood. Here, we identified a mechanism that couples the mi ...
SPRINGERNATURE2022Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression
Vassily Hatzimanikatis, Maria Masid Barcon, Ming Yang
Metabolic reprogramming is critical for tumor initiation and progression. However, the exact impact of specific metabolic changes on cancer progression is poorly understood. Here, we integrate multimodal analyses of primary and metastatic clonally-related ...
NATURE PORTFOLIO2022