Concept

Plasticité synaptique

Publications associées (485)

Enduring medial perforant path short-term synaptic depression at high pressure

The high pressure neurological syndrome develops during deep-diving (> 1.1 MPa) involving impairment of cognitive functions, alteration of synaptic transmission and increased excitability in cortico-hippocampal areas. The medial perforant path (MPP), conne ...

2010

Functional Requirements for Reward-Modulated Spike-Timing-Dependent Plasticity

Wulfram Gerstner, Nicolas Frémaux

Recent experiments have shown that spike-timing-dependent plasticity is influenced by neuromodulation. We derive theoretical conditions for successful learning of reward-related behavior for a large class of learning rules where Hebbian synaptic plasticity ...

Society for Neuroscience2010

Emergent Dynamics in Neocortical Microcircuits

Rodrigo de Campos Perin

Interactions among neurons can take place in a wide variety of forms. It is the goal of this thesis to investigate the properties and implications of a number of these interactions that we believe are relevant for information processing in the brain. Neuro ...

EPFL2010

Pro-neurogenesis therapy rescues hippocampal-mediated learning and memory deficits in the ts65dn mouse model of Down syndrome

Diego Ghezzi

Down syndrome (DS) is the most frequent cause of mental retardation in adults and children. It has been proposed that cognitive disabilities associated with DS may be ascribed to neurogenesis impairment during both development and adulthood. This view is s ...

2010

Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clusters

Steinunn Baekkeskov Hanahan

T he inhibitory neurotransmitter gamma-amino butyric acid (GABA) is synthesized by two isoforms of the enzyme glutamic acid decarboxylase (GAD): GAD65 and GAD67. Whereas GAD67 is constitutively active and produces >90% of GABA in the central nervous system ...

Rockefeller University Press2010

Connectivity reflects coding: a model of voltage-based STDP with homeostasis

Wulfram Gerstner, Eleni Vasilaki, Claudia Clopath

Electrophysiological connectivity patterns in cortex often have a few strong connections, which are sometimes bidirectional, among a lot of weak connections. To explain these connectivity patterns, we created a model of spike timing–dependent plasticity (S ...

Nature Publishing Group2010

Sound-driven modulation of sub- and suprathreshold activity in mouse primary visual cortex

Diego Ghezzi

Integration of multimodal information is essential for the integrative response of the brain and is thought to be accomplished mostly in sensory association areas. However, available evidences in humans and monkeys indicate that this process begins already ...

2010

STDP in adaptive neurons gives close-to-optimal information transmission

Wulfram Gerstner, Jean-Pascal Théodor Pfister, Guillaume Hennequin

Spike-frequency adaptation is known to enhance the transmission of information in sensory spiking neurons by rescaling the dynamic range for input processing, matching it to the temporal statistics of the sensory stimulus. Achieving maximal information tra ...

Frontiers Research Foundation2010

Role of NCAM in emotion and learning

Maria del Carmen Sandi Perez, Kamila Markram, Reto Bisaz, Lisa Conboy

NCAM is an abundant cell adhesion molecule known to be important during development. Together with its posttranslational modification consisting of the addition of the polysaccharide polysialic acid (PSA), NCAM has been classically implicated in the regula ...

2010

Phosphorylation of synucleins by members of the Polo-like kinase family

Hilal Lashuel, Harald Hirling, Magdalena Zweckstetter, Abid Oueslati, Martial Mbefo Kamdem

Phosphorylation of alpha-synuclein (alpha-syn) at Ser-129 is a hallmark of Parkinson disease and related synucleinopathies. However, the identity of the natural kinases and phosphatases responsible for regulating alpha-syn phosphorylation remain unknown. H ...

American Society for Biochemistry and Molecular Biology2010

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