Concept

Plasticité synaptique

Publications associées (485)

Networks of Mixed Canonic-Dissipative Systems and Dynamic Hebbian Learning

We consider a collection {O_k}_{k=1}^N of interacting parametric mixed canonical-dissipative systems, (MCD). Each individual Ok, exhibits, in absence of interaction, a limit cycle L_k on which the orbit circulation is parameterized by w_k(t). The underlyin ...

Shaker Verlag2008

Step training reinforces specific spinal locomotor circuitry in adult spinal rats

Grégoire Courtine, Rubia van den Brand

Locomotor training improves function after a spinal cord injury both in experimental and clinical settings. The activity-dependent mechanisms underlying such improvement, however, are sparsely understood. Adult rats received a complete spinal cord transect ...

2008

Internal body state influences topographical plasticity of sensory representations in the rat gustatory cortex

Riccardo Accolla

Primary sensory cortices are remarkably organized in spatial maps according to specific sensory features of the stimuli. These cortical maps can undergo plastic rearrangements after changes in afferent ("bottom-up") sensory inputs such as peripheral lesion ...

2008

A limited contribution of Ca2+ current facilitation to paired-pulse facilitation of transmitter release at the rat calyx of Held

Ralf Schneggenburger, Martin Guillermo Mueller

Recent studies have suggested that transmitter release facilitation at synapses is largely mediated by presynaptic Ca2+ current facilitation, but the exact contribution of Ca2+ current facilitation has not been determined quantitatively. Here, we determine ...

2008

The role of the amygdala in emotional memories

Maria del Carmen Sandi Perez, Kamila Markram

This thesis investigates the role of the amygdala for the establishment of fear memories with a multidisciplinary approach, including behavioural, psychopharmacological, genetic, molecular, and electrophysiological techniques in rats or mice, under healthy ...

EPFL2007

Consideration of the effect of the anesthesia in the thalamocortical assemblies

Martin Hasler, Kumiko Oshima, Borja Ibarz Gabardos

Despite intensive research efforts, the effects of anesthesia on brain physiology and function have not been satisfactorily explained yet. Nevertheless, from what has been discovered up to now, we can attribute the effect of the anesthetics to changes in c ...

2007

Optimality Model of Unsupervised Spike-Timing Dependent Plasticity: Synaptic Memory and Weight Distribution

Wulfram Gerstner, Jean-Pascal Théodor Pfister, Taro Toyoizumi

We studied the hypothesis that synaptic dynamics is controlled by three basic principles: (1) synapses adapt their weights so that neurons can effectively transmit information, (2) homeostatic processes stabilize the mean firing rate of the postsynaptic ne ...

Massachusetts Institute of Technology Press2007

Elevated NMDA receptor levels and enhanced postsynaptic long-term potentiation induced by prenatal exposure to valproic acid

Henry Markram, Tania Rinaldi

Valproic acid (VPA) is a powerful teratogen causing birth defects in humans, including autism spectrum disorder (ASD), if exposure occurs during the first trimester of embryogenesis. Learning and memory alterations are common symptoms of ASD, but underlyin ...

2007

Structure and dynamics of the neocortical microcircuit connectivity

Jean-Vincent Le Bé

The neocortex is the most computationally advanced portion of the brain. It is currently assumed to be composed of a large number of "cortical columns" – intricate arrangements of cortical neurons approximately 300-500 µm in diameter and 2-5 mm in height i ...

EPFL2007

TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity

Pierre Magistretti, Kim Do, Jean-René Cardinaux

A key feature of memory processes is to link different input signals by association and to preserve this coupling at the level of synaptic connections. Late-phase long-term potentiation (L-LTP), a form of synaptic plasticity thought to encode long-term mem ...

2007

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