Concept
Weakness
Publications associées (8)
Mitochondrial Creatine Kinase Attenuates Pathologic Remodeling in Heart Failure
Yi Zhang, Annina Stuber, Ashish Gupta
BACKGROUND: Abnormalities in cardiac energy metabolism occur in heart failure (HF) and contribute to contractile dysfunction, but their role, if any, in HF-related pathologic remodeling is much less established. CK (creatine kinase), the primary muscle ene ...
LIPPINCOTT WILLIAMS & WILKINS2022Hybrid peripheral-spinal neuroprosthesis for refined motor execution after paralysis
Spinal cord injury (SCI) disrupts the communication between the brain and the spinal circuits responsible for movement, thereby causing severe motor deficits. Current strategies to restore function to paralyzed limbs have separately investigated electrical ...
EPFL2018Dysfunction in endoplasmic reticulum-mitochondria crosstalk underlies SIGMAR1 loss of function mediated motor neuron degeneration
Roman Chrast, Nathalie Marie Géraldine Bernard
Mutations in SIGMAR1, which encodes the Sigma 1 receptor, cause a familial form of amyotrophic lateral sclerosis, but the underlying molecular mechanisms are unclear. Bernard-Marissal et al. reveal that disruption of Sigma 1 receptor function disturbs endo ...
Oxford University Press2015Biped gait controller for large speed variations, combining reflexes and a central pattern generator in a neuromuscular model
Auke Ijspeert, Renaud Ronsse, Nicolas Benoît Dominique Van der Noot
Controllers based on neuromuscular models hold the promise of energy-efficient and human-like walkers. However, most of them rely on optimizations or cumbersome hand-tuning to find controller parameters which, in turn, are usually working for a specific ga ...
IEEE2015A Neuromuscular Model for Symbiotic Man-Machine Exoskeleton Control Accounting for Patient Impairment Specificity
Auke Ijspeert, Etienne Burdet, Florin Dzeladini
Millions of people worldwide live with impaired locomotion. The degree of impairment is highly variable and the causes are multiple. This variation necessitates the design of a new generation of exoskeleton controllers for personalised, symbiotic man-machi ...
2014Assessment of Body Motion and Muscle Weakness
Muscle weakness is a common symptom in elderly population and in children with Duchenne muscular dystrophy (DMD), causing impaired mobility. DMD is a devastating degenerative disease caused by a mutation in the dystrophin gene, leading to the absence of th ...
EPFL2011Spatially Distributed Sequential Stimulation Reduces Fatigue in Paralyzed Triceps Surae Muscles: A Case Study
Functional electrical stimulation (FES) is limited by the rapid onset of muscle fatigue caused by localized nerve excitation repeatedly activating only a subset of motor units. The purpose of this study was to investigate reducing fatigue by sequentially c ...
2011Overexpression of inositol 1,4,5-trisphosphate 3-kinase in Xenopus oocytes inhibits agonist-evoked capacitative calcium entry
Ins(1,4,5)P3 3-kinase is a key enzyme in the regulation of Ins(1,4,5)P3. Overexpression of Ins(1,4,5)P3 3-kinase inhibited agonist-evoked and Ins(1,3,4,5)P4-evoked Ca2+ entry in Xenopus oocytes, but did not inhibit Ca2+ entry evoked by thapsigargin or non- ...
1994