Concept

Métabolisme acide crassulacéen

Publications associées (45)

In silico tracing of the fate of single carbon atoms in different physiological states of E. coli

Jasmin Maria Hafner, Noushin Hadadi, Beatriz Lopes Pinto Basto Carreira

Many applications of systems biology such as the simulation of isotope labeling experiments and pathway inference in metabolic engineering rely on atom-level representation of metabolism. Because of its challenging complexity and the difficulty of obtainin ...

2018

Hyperpolarized C-13 Magnetic Resonance Spectroscopy Reveals the Rate-Limiting Role of the Blood-Brain Barrier in the Cerebral Uptake and Metabolism of L-Lactate in Vivo

Bernard Lanz, Mor-Miri Mishkovsky, Tian Cheng, Arnaud Comment, Josefina Adriana Maria Bastiaansen, Hikari Ananda Infinity Yoshihara, Sylvain Eric Lengacher, Yuhei Takado

The dynamics of L-lactate transport across the blood-brain barrier (BBB) and its cerebral metabolism are still subject to debate. We studied lactate uptake and intracellular metabolism in the mouse brain using hyperpolarized C-13 magnetic resonance spectro ...

2018

Circadian Rhythms and Mitochondria: Connecting the Dots

Carlos Canto Alvarez, Miriam Valera Alberni

Circadian rhythms provide a selective advantage by anticipating organismal nutrient needs and guaranteeing optimal metabolic capacity during active hours. Impairment of circadian rhythms is associated with increased risk of type 2 diabetes and emerging evi ...

FRONTIERS MEDIA SA2018

Understanding reprogramming of cancer cell metabolism using metabolic modeling

Vassily Hatzimanikatis, Maria Masid Barcon, Joana Raquel Pinto Vieira

Cancer cells have been observed to undergo a metabolic reprogramming in which glycolytic fluxes are upregulated whereas oxidative phosphorylation is downregulated. This metabolic phenotype is known as theWarburg effect and it is observed even under high ox ...

2017

redGEM: Systematic reduction and analysis of genome-scale metabolic reconstructions for development of consistent core metabolic models

Vassily Hatzimanikatis, Meriç Ataman, Georgios Fengos, Daniel Federico Hernandez Gardiol

Genome-scale metabolic reconstructions have proven to be valuable resources in enhancing our understanding of metabolic networks as they encapsulate all known metabolic capabilities of the organisms from genes to proteins to their functions. However the co ...

2017

Adenosine A(1) receptors control the metabolic recovery after hypoxia in rat hippocampal slices

João Miguel das Neves Duarte

Adenosine is a neuromodulator that protects neurons from hypoxia. This effect is attributed to the ability of adenosine A(1) receptors (A(1)R) to inhibit excitatory synaptic transmission. However, A(1)R activation also protects non-brain tissues from hypox ...

Wiley-Blackwell2016

Dehalobacter – a genus of anaerobic bacteria dedicated to organohalide degradation

Christof Holliger, Julien Maillard

Abstract The genus Dehalobacter embraces bacterial populations that seem to exclusively degrade organohalides. All isolates in pure culture and highly enriched strains are obligate organohalide-respiring bacteria that use hydrogen as energy and electron so ...

Springer-Verlag2016

Mitonuclear communication in homeostasis and stress

Johan Auwerx, Adrienne Joëlle Laurence Mottis

Mitochondria participate in crucial cellular processes such as energy harvesting and intermediate metabolism. Although mitochondria possess their own genome - a vestige of their bacterial origins and endosymbiotic evolution - most mitochondrial proteins ar ...

Nature Publishing Group2016

“ATLAS of Biochemistry”: A repository of all possible biochemical reactions for synthetic biology, metabolic engineering and metabolomics studies

Vassily Hatzimanikatis, Jasmin Maria Hafner, Adrian Shajkofci, Noushin Hadadi, Aikaterini Zisaki

Recent technical and analytical progress in the field of metabolomics has lead to the identification of vast amounts of new compounds in living organisms. However, the integration of these compounds into the context of known metabolism remains difficult. T ...

2016

Characterization of intracellular metabolic states in the origin of the metabolic reprogramming of cancer cells

Vassily Hatzimanikatis, Meriç Ataman, Joana Raquel Pinto Vieira

Cancer cells have been observed to undergo a metabolic reprogramming in which glycolytic fluxes are upregulated whereas oxidative phosphorylation is downregulated. This metabolic phenotype is known as the Warburg effect and it is observed even under high o ...

2015

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