Concept
Maladie du charbon
Publications associées (34)
S-acylation and lipid exchange at the ER-Golgi membrane contact sites regulate pathogen entry in human cells
Cells have evolved endocytic pathways to internalize different molecules, to regulate intra-cellular communication and their interaction with external environment. Pathogens have co-evolved with cells to exploit these processes for infections. In particula ...
EPFL2024Stability of influenza A virus in droplets and aerosols is heightened by the presence of commensal respiratory bacteria
Athanasios Nenes, Tamar Kohn, Kalliopi Violaki, Ghislain Gilles Jean-Michel Motos, Aline Laetitia Schaub, Shannon Christa David, Walter Hugentobler, Htet Kyi Wynn, Céline Terrettaz, Laura José Costa Henriques, Daniel Scott Nolan, Marta Augugliaro
Aerosol transmission remains a major challenge for control of respiratory viruses, particularly those causing recurrent epidemics, like influenza A virus (IAV). These viruses are rarely expelled alone, but instead are embedded in a consortium of microorgan ...
2024The tip protein PAAR is required for the function of the type VI secretion system
Bacteria are constantly competing to colonize crowded ecological niches, such as the human gut. The type VI secretion system (T6SS) is a critical bacterial weapon in this warfare. It resembles a crossbow with a poisoned arrow allowing bacteria to inject to ...
Washington2023Harnessing the Membrane Translocation Properties of AB Toxins for Therapeutic Applications
Françoise Gisou van der Goot Grunberg
Over the last few decades, proteins and peptides have become increasingly more common as FDA-approved drugs, despite their inefficient delivery due to their inability to cross the plasma membrane. In this context, bacterial two-component systems, termed AB ...
2021Anthrax toxin requires ZDHHC5-mediated palmitoylation of its surface-processing host enzymes
Françoise Gisou van der Goot Grunberg, Oksana Andrei Sergeeva
The protein acyl transferase ZDHHC5 was recently proposed to regulate trafficking in the endocytic pathway. Therefore, we explored the function of this enzyme in controlling the action of bacterial toxins. We found that ZDHHC5 activity is required for two ...
2019A review of the concepts, recent advances and niche applications of the (photo) Fenton process, beyond water/wastewater treatment: Surface functionalization, biomass treatment, combatting cancer and other medical uses
The Fenton reaction was discovered over 120 years ago, yet our understanding of the complete reaction mechanism of the seemingly simple iron and hydrogen peroxide reaction (Fe + H2O2) remains unclear, thus limiting its full potential. In this work, the aim ...
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