Concept

WormBase

WormBase is an online biological database about the biology and genome of the nematode model organism Caenorhabditis elegans and contains information about other related nematodes. WormBase is used by the C. elegans research community both as an information resource and as a place to publish and distribute their results. The database is regularly updated with new versions being released every two months. WormBase is one of the organizations participating in the Generic Model Organism Database (GMOD) project. WormBase comprises the following main data sets: The annotated genomes of Caenorhabditis elegans, Caenorhabditis briggsae, Caenorhabditis remanei, Caenorhabditis brenneri, Caenorhabditis angaria, Pristionchus pacificus, Haemonchus contortus, Meloidogyne hapla, Meloidogyne incognita, Brugia malayi and Onchocerca volvulus; Hand-curated annotations describing the function of ~20,500 C. elegans protein-coding genes and ~16,000 C. elegans non-coding genes; Gene families; Orthologies; Genomic transcription factor binding sites Comprehensive information on mutant alleles and their phenotypes; Whole-genome RNAi (RNA interference) screens; Genetic maps, markers and polymorphisms; The C. elegans physical map; Gene expression profiles (stage, tissue and cell) from microarrays, SAGE analysis and GFP promoter fusions; The complete cell lineage of the worm; The wiring diagram of the worm nervous system; Protein-protein interaction Interactome data; Genetic regulatory relationships; Details of intra- and inter-specific sequence homologies (with links to other Model Organism Databases). In addition, WormBase contains an up-to-date searchable bibliography of C. elegans research and is linked to the WormBook project. WormBase offers many ways of searching and retrieving data from the database: WormMart, Wiki - was a tool for retrieving varied information on many genes (or the sequences of those genes). This was the WormBase implementation of BioMart. WormMine, Wiki - as of 2016, the primary data mining facility.

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