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WormBase

Publications associées (14)

Microfluidic devices for automated analysis of ingested bacteria in the Caenorhabditis elegans intestine

In this thesis, we explored on-chip high-resolution imaging of the fate of intestinal bacteria and bacterial products in Caenorhabditis elegans (C. elegans). In the first part, we carried out high-resolution z-stack fluorescent imaging of Red Fluorescent P ...

EPFL2023

An In Vivo Microfluidic Study of Bacterial Load Dynamics and Absorption in the C. elegans Intestine

Martinus Gijs, Thomas Lehnert, Vittorio Viri, Maël Arveiler

Caenorhabditiselegans (C. elegans) has gained importance as a model for studying host-microbiota interactions and bacterial infections related to human pathogens. Assessing the fate of ingested bacteria in the worm's intestine is therefore of great interes ...

MDPI2021

Automated Platform for Long-Term Culture and High-Content Phenotyping of Single C. elegans Worms

Johan Auwerx, Martinus Gijs, Matteo Cornaglia, Laurent Mouchiroud, Elena Katsyuba, Hüseyin Baris Atakan, Rongrong Xiang

The nematode Caenorhabditis elegans is a suitable model organism in drug screening. Traditionally worms are grown on agar plates, posing many challenges for long-term culture and phenotyping of animals under identical conditions. Microfluidics allows for ' ...

2019

Microfluidic and micromechanical in vivo studies of Caenorhabditis elegans

Roger Philippe Krenger

Caenorhabditis elegans is one of the most attractive model organisms in biomedical research for understanding human diseases and for drug testing at a whole-organism level, since many biological pathways and genes have been conserved between itself and hum ...

EPFL2019

Long-term imaging, automated high-content phenotyping and sorting of C. elegans larvae and embryos using microfluidic platforms

Hüseyin Baris Atakan

C. elegans is frequently studied to address fundamental biological questions motivated by its short life cycle, small size, hermaphrodite behavior and well-annotated genome. In this work, we present novel microfluidic platforms that support long-term cultu ...

EPFL2019

Lab-on-a-chip technologies for manipulation and imaging of C. elegans worms and embryos

Li Dong

The nematode Caenorhabditis elegans is an attractive model organism, owing notably to its short life cycle, genetic tractability, and optical transparency facilitating microscopic observation. This thesis deals with the realization of technological tools f ...

EPFL2018

Size-dependent sorting of C. elegans nematodes through an adjustable microfluidic filter structure.

Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Li Dong

We introduce a new and simple microfluidic sorting device based on adjustable filter structures that can be easily tuned by external pressure for a specific size-dependent C. elegans worm sorting experiment. A single device can be used for selecting and so ...

2016

Cellular hallmarks reveal restricted aerobic metabolism at thermal limits

Pierre Gönczy, Coralie Busso, Aitana Neves da Silva

All organisms live within a given thermal range, but little is known about the mechanisms setting the limits of this range. We uncovered cellular features exhibiting signature changes at thermal limits in Caenorhabditis elegans embryos. These included chan ...

eLife Sciences Organisation2015

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C-elegans

Johan Auwerx, Laurent Mouchiroud, Pénélope Andreux, Richardus Houtkooper, Xu Wang, Norman Lionel Moullan, Adrienne Joëlle Laurence Mottis, Virginija Jovaisaite, Sabrina Bichet

Mitochondria are semi-autonomous organelles regulated by a complex network of proteins that are vital for many cellular functions. Because mitochondrial modulators can impact many aspects of cellular homeostasis, their identification and validation has pro ...

Nature Publishing Group2014

Cross-species and cross-platform gene expression studies with the Bioconductor-compliant R package 'annotationTools'

Mauro Delorenzi

BACKGROUND: The variety of DNA microarray formats and datasets presently available offers an unprecedented opportunity to perform insightful comparisons of heterogeneous data. Cross-species studies, in particular, have the power of identifying conserved, f ...

BioMed Central2008

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