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Publications associées (55)
Comparison of Three Viral Nucleic Acid Preamplification Pipelines for Sewage Viral Metagenomics
Tamar Kohn, Xavier Fernandez Cassi
Viral metagenomics is a useful tool for detecting multiple human viruses in urban sewage. However, more refined protocols are required for its effective use in disease surveillance. In this study, we investigated the performance of three different preampli ...
2024Viral diversity is linked to bacterial community composition in alpine stream biofilms
Tom Ian Battin, Hannes Markus Peter, Paraskevi Pramateftaki, Meriem Bekliz
Biofilms play pivotal roles in fluvial ecosystems, yet virtually nothing is known about viruses in these communities. Leveraging an optimized sample-to-sequence pipeline, we studied the spatiotemporal turnover of dsDNA viruses associated with stream biofil ...
Springer2022Antiviral Screen against Canine Distemper Virus-Induced Membrane Fusion Activity
Gerardo Turcatti, Marc Chambon, Jonathan Patrice Vesin
Canine distemper virus (CDV), a close relative of the human pathogen measles virus (MeV), is an enveloped, negative sense RNA virus that belongs to the genus Morbillivirus and causes severe diseases in dogs and other carnivores. Although the vaccination i ...
2021Towards an artificial cell: Development of a system which self-regenerates the protein components of the PURE system in microfluidic reactors
Thanks to recent advancements in synthetic biology, the dream of creating a synthetic cell has become feasible. However, due to its inherent complexity, one of the fundamental functions of all living systems, i.e., self-replication, remains to be introduce ...
EPFL2021Deep Learning Enables Individual Xenograft Cell Classification in Histological Images by Analysis of Contextual Features
Michaël Unser, Cathrin Brisken, Daniel Sage, Olivier Burri, Martin Weigert, Fabio De Martino, Quentin Juppet
Patient-Derived Xenografts (PDXs) are the preclinical models which best recapitulate inter- and intra-patient complexity of human breast malignancies, and are also emerging as useful tools to study the normal breast epithelium. However, data analysis gener ...
2021Requirements for DNA bubble structure for efficient cleavage by helix-two-turn-helix DNA glycosylases
Oxidative DNA lesions, constantly generated by both endogenous and environmentally induced reactive oxygen species, are removed via the base excision repair pathway. In bacteria, Fpg and Nei DNA glycosylases, belonging to the helix-two-turn-helix (H2TH) st ...
2020