Concept

Thérapie systémique

Publications associées (9)

Optimized Modeling of Metastatic Triple-Negative Invasive Lobular Breast Carcinoma

Cathrin Brisken, Georgios Sflomos, Laura Battista

Simple Summary Invasive lobular carcinoma (ILC) is the second most common histologic subtype of breast cancer and is often detected at an advanced stage. Up to 30% of ILC cases relapse and present a challenge for treatment. Unfortunately, there are few mod ...

MDPI2023

A systemic framework to categorize Circular Economy interventions: An application to the construction and demolition sector

Claudia Rebeca Binder Signer, Valeria Superti, Cynthia Houmani

The Circular Economy (CE) concept has recently gained momentum as a perspective to tackle global challenges such as resource scarcity and waste management. Multiple types of interventions have been proposed to support the transition towards a CE. This pape ...

2021

Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer

Candice Megan T Young

Pancreatic cancer is the most lethal common solid malignancy. Systemic therapies are often ineffective, and predictive biomarkers to guide treatment are urgently needed. We generated a pancreatic cancer patient-derived organoid (PDO) library that recapitul ...

2018

More Medicines for Tuberculosis: Fuelling Drug Discovery against Mycobacterium tuberculosis

Shi-Yan Caroline Foo

Tuberculosis (TB), whose etiological agent is Mycobacterium tuberculosis (M. tuberculosis), has plagued humanity since antiquity. Even with chemotherapy available today, TB is the leading cause of death due to an infectious disease. Modern day factors, suc ...

EPFL2018

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

Kristina Schoonjans, Alessia Perino

The systemic expression of the bile acid (BA) sensor farnesoid X receptor (FXR) has led to promising new therapies targeting cholesterol metabolism, triglyceride production, hepatic steatosis and biliary cholestasis. In contrast to systemic therapy, bile a ...

Nature Publishing Group2015

Extracellular Matrix-Inspired Growth Factor Delivery Systems for Skin Wound Healing

Jeffrey Alan Hubbell, Mikaël Martino, Priscilla Suhasna Maithili Briquez

Significance: Growth factors are very promising molecules for the treatment of skin wounds. However, their translation to clinical use has been seriously limited, facing issues related to safety and cost-effectiveness. These problems may derive from the fa ...

Mary Ann Liebert, Inc2015

Design Methodology and Innovative Device Concept for Acoustic Hearing Implants

Hans Bernhard

Nowadays, hearing impaired people can be treated with a multitude of different devices and surgical interventions that are selected in function of the type and degree of hearing loss of the patient. These known therapies cover the major part of possible he ...

EPFL2011

Survival Benefit With Proapoptotic Molecular and Pathologic Responses From Dual Targeting of Mammalian Target of Rapamycin and Epidermal Growth Factor Receptor in a Preclinical Model of Pancreatic Neuroendocrine Carcinogenesis

Douglas Hanahan

Purpose Pancreatic neuroendocrine tumors (PNETs), although rare, often metastasize, such that surgery, the only potentially curative therapy, is not possible. There is no effective systemic therapy for patients with advanced PNETs. Therefore, new strategie ...

American Society of Clinical Oncology2010

Building exposure: synergy of interaction and narration through the social channel

Daniel Thalmann, Bruno Herbelin, Michal Ponder

The ability to build and control exposure through a seamless synergy of interaction and narration is a strongly required feature of a new type of immersive-VR training and therapy system. This paper presents a practical approach for immersive-VR training a ...

MIT Press2005

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