Publications associées à Empreinte génétique

Emerging dimensions of cellular cGAS-STING signaling

Andrea Ablasser, Baptiste Claude André Guey

The recognition of DNA through the cGAS-STING pathway plays a critical role in antiviral immunity, but can also drive maladaptive immune responses underlying several pathological conditions. Despite its importance, understanding the organization of cGAS-ST ...

2022

A simple micropreparative gel electrophoresis technique for purification of proteins, nucleic acids, and bioconjugates

Ardemis Anoush Boghossian, Sayyed Hashem Sajjadi, Shang-Jung Wu, Vitalijs Zubkovs

The biochemical and biomedical fields hinge on the ability to effectively separate and purify biological macromolecules. Though this need is largely addressed with a variety of chromatographic and electrophoretic purification techniques, such techniques ar ...

2021

m6A methylation potentiates cytosolic dsDNA recognition in a sequence-specific manner

Andrea Ablasser, Muhammet Fatih Gülen

Nucleic acid sensing through pattern recognition receptors is critical for immune recognition of microbial infections. Microbial DNA is frequently methylated at the N-6 position of adenines (m6A), a modification that is rare in mammalian host DNA. We show ...

ROYAL SOC2021

Directed evolution of DNA-wrapped single-walled carbon nanotube complexes for optical sensing

Benjamin Paul Johanès Gabriel Lambert

Single-walled carbon nanotubes (SWCNTs) have garnered significant interest for their applications in optical biosensing. SWCNTs exhibit a sensitive and photostable fluorescence in the near-infrared (NIR) range, allowing for the continuous monitoring of tar ...

EPFL2021

Relief of ParB autoinhibition by parS DNA catalysis and recycling of ParB by CTP hydrolysis promote bacterial centromere assembly

Paolo De Los Rios, Stefano Zamuner

Three-component ParABS systems are widely distributed factors for plasmid partitioning and chromosome segregation in bacteria. ParB acts as adaptor protein between the 16-base pair centromeric parS DNA sequences and the DNA segregation proteins ParA and Sm ...

AMER ASSOC ADVANCEMENT SCIENCE2021

Interplay of cGAS with chromatin

Andrea Ablasser, Marilena Wischnewski

Recognition of DNA is an evolutionarily highly conserved mechanism of immunity. In mammals, the cGAS-STING pathway plays a central role in coupling DNA sensing to the execution of innate immune mechanisms, both in contexts of infection as well as in noninf ...

ELSEVIER SCIENCE LONDON2021

Gain-switched semiconductor laser driven soliton microcombs

Tobias Kippenberg, Junqiu Liu, Erwan Guillaume Albert Lucas, Wenle Weng, Jijun He

Dissipative Kerr soliton generation using self-injection-locked III-V lasers has enabled fully integrated hybrid microcombs that operate in turnkey mode and can access microwave repetition rates. Yet, continuous-wave-driven soliton microcombs exhibit low e ...

NATURE RESEARCH2021

Redox Properties of Native and Damaged DNA from Mixed Quantum Mechanical/Molecular Mechanics Molecular Dynamics Simulations

Ursula Röthlisberger, Ivano Tavernelli, Polydefkis Diamantis

The redox properties of two large DNA fragments composed of 39 base pairs, differing only by an 8-oxoguanine (8oxoG) defect replacing a guanine (G), were investigated in physiological conditions using mixed quantum mechanical/molecular mechanical (QM/MM) m ...

AMER CHEMICAL SOC2020

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Empreinte génétique

Emerging dimensions of cellular cGAS-STING signaling

Microfluidic systems for in-flow bioanalytes collection

A simple micropreparative gel electrophoresis technique for purification of proteins, nucleic acids, and bioconjugates

m6A methylation potentiates cytosolic dsDNA recognition in a sequence-specific manner

Directed evolution of DNA-wrapped single-walled carbon nanotube complexes for optical sensing

Relief of ParB autoinhibition by parS DNA catalysis and recycling of ParB by CTP hydrolysis promote bacterial centromere assembly

On the Characterisation of the Surface Roughness of 3d Object Scanned with Micro CT

Interplay of cGAS with chromatin

Gain-switched semiconductor laser driven soliton microcombs

Redox Properties of Native and Damaged DNA from Mixed Quantum Mechanical/Molecular Mechanics Molecular Dynamics Simulations

Graph Chatbot

Chattez avec Graph Search

On the Characterisation of the Surface Roughness of 3d Object Scanned with Micro CT

m6A methylation potentiates cytosolic dsDNA recognition in a sequence-specific manner

Directed evolution of DNA-wrapped single-walled carbon nanotube complexes for optical sensing

Microfluidic systems for in-flow bioanalytes collection

A simple micropreparative gel electrophoresis technique for purification of proteins, nucleic acids, and bioconjugates

Gain-switched semiconductor laser driven soliton microcombs

Relief of ParB autoinhibition by parS DNA catalysis and recycling of ParB by CTP hydrolysis promote bacterial centromere assembly

Interplay of cGAS with chromatin

Redox Properties of Native and Damaged DNA from Mixed Quantum Mechanical/Molecular Mechanics Molecular Dynamics Simulations

Emerging dimensions of cellular cGAS-STING signaling