Publications associées à Différenciation dirigée

Daniel Constam, Sylvain Frédéric Bessonnard

The first cell differentiation in mammalian embryos segregates polarized trophectoderm cells from an apolar inner cell mass (ICM). This lineage decision is specified in compacted morulae by cell polarization and adhesion acting on the Yes-associated protei ...

Rockefeller Univ Press2015

Possibilities in Germ Cell Research: An Engineering Insight

Omid Mashinchian, Morteza Mahmoudi

Germ cells (GCs) are responsible for fertility and disruptions in their development or function cause infertility. However, current knowledge about the diverse mechanisms involved in GC development and function is still in its infancy. This is mainly becau ...

Elsevier Science London2015

Stem cell niche engineering through droplet microfluidics

Matthias Lütolf, Simone Allazetta

Stem cells reside in complex niches in which their behaviour is tightly regulated by various biochemical and biophysical signals. In order to unveil some of the crucial stem cell-niche interactions and expedite the implementation of stem cells in clinical ...

Current Biology Ltd2015

Substrate elasticity modulates the responsiveness of mesenchymal stem cells to commitment cues

Matthias Lütolf, Samy Gobaa

Fate choices of stem cells are regulated in response to a complex array of biochemical and physical signals from their microenvironmental niche. Whereas the molecular composition and the role of mechanical niche cues have been extensively studied, relative ...

Royal Soc Chemistry2015

Harmonic Nanoparticles for Regenerative Research

Jean-Pierre Wolf, Jérôme Extermann, Luigi Bonacina

In this visualized experiment, protocol details are provided for in vitro labeling of human embryonic stem cells (hESC) with second harmonic generation nanoparticles (HNPs). The latter are a new family of probes recently introduced for labeling biological ...

Journal Of Visualized Experiments2014

Nodal.Gdf1 Heterodimers with Bound Prodomains Enable Serum-independent Nodal Signaling and Endoderm Differentiation

Daniel Constam, Christophe Fuerer

The TGF beta family member Nodal is central to control pluripotent stem cell fate, but its use as a stem cell differentiation factor is limited by low specific activity. During development, Nodal depends on growth and differentiation factor (Gdf)-1 and on ...

American Society for Biochemistry and Molecular Biology2014

Loss of MITF expression during human embryonic stem cell differentiation disrupts retinal pigment epithelium development and optic vesicle cell proliferation

Bernard Schneider

Microphthalmia-associated transcription factor (MITF) is a master regulator of pigmented cell survival and differentiation with direct transcriptional links to cell cycle, apoptosis and pigmentation. In mouse, Mitf is expressed early and uniformly in optic ...

Oxford University Press2014

Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy using Human Induced Pluripotent Stem Cells

Henning Paul-Julius Stahlberg, Michael Weber

Diabetic cardiomyopathy is a complication of type 2 diabetes, with known contributions of lifestyle and genetics. We develop environmentally and genetically driven in vitro models of the condition using human-induced-pluripotent-stem-cell-derived cardiomyo ...

Elsevier BV2014

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

Bernard Schneider, Liliane Glauser, Elpida Tsika, Darren Moore, Guillaume Daniel, Aris Nikolaos Fiser

Mutations in the vacuolar protein sorting 35 homolog (VPS35) gene at the PARK17 locus, encoding a key component of the retromer complex, were recently identified as a new cause of late-onset, autosomal dominant Parkinson's disease (PD). Here we explore the ...

Oxford University Press2014

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Différenciation dirigée

PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation

Possibilities in Germ Cell Research: An Engineering Insight

Stem cell niche engineering through droplet microfluidics

Substrate elasticity modulates the responsiveness of mesenchymal stem cells to commitment cues

Harmonic Nanoparticles for Regenerative Research

Nodal.Gdf1 Heterodimers with Bound Prodomains Enable Serum-independent Nodal Signaling and Endoderm Differentiation

Loss of MITF expression during human embryonic stem cell differentiation disrupts retinal pigment epithelium development and optic vesicle cell proliferation

Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy using Human Induced Pluripotent Stem Cells

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

A cell engineering strategy to enhance the safety of stem cell therapies

Graph Chatbot

Chattez avec Graph Search

PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation

Stem cell niche engineering through droplet microfluidics

A cell engineering strategy to enhance the safety of stem cell therapies

Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy using Human Induced Pluripotent Stem Cells

Possibilities in Germ Cell Research: An Engineering Insight

Harmonic Nanoparticles for Regenerative Research

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

Loss of MITF expression during human embryonic stem cell differentiation disrupts retinal pigment epithelium development and optic vesicle cell proliferation

Substrate elasticity modulates the responsiveness of mesenchymal stem cells to commitment cues

Nodal.Gdf1 Heterodimers with Bound Prodomains Enable Serum-independent Nodal Signaling and Endoderm Differentiation