Concept

Phagocyte

Publications associées (106)

Collecting Lymphatic Vessel Permeability Facilitates Adipose Tissue Inflammation and Distribution of Antigen to Lymph Node-Homing Adipose Tissue Dendritic Cells

Collecting lymphatic vessels (CLVs), surrounded by fat and endowed with contractile muscle and valves, transport lymph from tissues after it is absorbed into lymphatic capillaries. CLVs are not known to participate in immune responses. In this study, we ob ...

Amer Assoc Immunologists2015

The Black cells phenotype is caused by a point mutation in the Drosophila pro-phenoloxidase 1 gene that triggers melanization and hematopoietic defects

Bruno Lemaitre, Maroun Bou Sleiman, Olivier Binggeli, Lise Bertin

Melanization contributes to arthropod-specific innate immunity through deposition of melanin at wound sites or around parasites, with concomitant release of microbicidal reactive oxygen species. Melanization requires sequential activation of proteolytic en ...

Elsevier2015

Engineering antigen-specific immunological tolerance

Stephane Kontos, Jeffrey Alan Hubbell, Alizée Jéléna Grimm

Unwanted immunity develops in response to many protein drugs, in autoimmunity, in allergy, and in transplantation. Approaches to induce immunological tolerance aim to either prevent these responses or reverse them after they have already taken place. We pr ...

Current Biology Ltd2015

Dual-regulated Lentiviral Vector for Gene Therapy of X-linked Chronic Granulomatosis

Didier Trono

Regulated transgene expression may improve the safety and efficacy of hematopoietic stem cell (HSC) gene therapy. Clinical trials for X-linked chronic granulomatous disease (X-CGD) employing gammaretroviral vectors were limited by insertional oncogenesis o ...

Elsevier2014

Steady-State Antigen Scavenging, Cross-Presentation, and CD8(+) T Cell Priming: A New Role for Lymphatic Endothelial Cells

Marcela Rincón-Restrepo, Efthymia Vokali, Melody Swartz, Sachiko Hirosue, Amanda Waite Lund, Patricia Corthésy Henrioud, Vidya Raghavan

Until recently, the known roles of lymphatic endothelial cells (LECs) in immune modulation were limited to directing immune cell trafficking and passively transporting peripheral Ags to lymph nodes. Recent studies demonstrated that LECs can directly suppre ...

Amer Assoc Immunologists2014

Optimization and regeneration kinetics of lymphatic-specific photodynamic therapy in the mouse dermis

Melody Swartz, Patrycja Nowak-Sliwinska, Witold Waldemar Kilarski, Renata Katarzyna Mezyk-Kopec

Lymphatic vessels transport fluid, antigens, and immune cells to the lymph nodes to orchestrate adaptive immunity and maintain peripheral tolerance. Lymphangiogenesis has been associated with inflammation, cancer metastasis, autoimmunity, tolerance and tra ...

Springer2014

The C-type Lectin Receptors Dectin-1, MR, and SIGNR3 Contribute Both Positively and Negatively to the Macrophage Response to Leishmania infantum

Johan Auwerx

Macrophages act as the primary effector cells during Leishmania infection through production of reactive oxygen species (ROS) and interleukin-1 beta (IL-1 beta). However, how macrophage-killing mechanisms are activated during Leishmania-macrophage interact ...

Elsevier2013

Closing the gap between T-cell life span estimates from stable isotope-labeling studies in mice and humans

Istvan Bartha

Quantitative knowledge of the turnover of different leukocyte populations is a key to our understanding of immune function in health and disease. Much progress has been made thanks to the introduction of stable isotope labeling, the state-of-the-art techni ...

Amer Soc Hematology2013

Mycobacterium tuberculosis Requires Phosphate-Responsive Gene Regulation To Resist Host Immunity

John McKinney, Anna De Graff Tischler

Mycobacterium tuberculosis persists in the tissues of mammalian hosts despite inducing a robust immune response dominated by the macrophage-activating cytokine gamma interferon (IFN-gamma). We identified the M. tuberculosis phosphate-specific transport (Ps ...

American Society for Microbiology2013

Stiffness tomography exploration of living and fixed macrophages

Giovanni Dietler, Sandor Kasas, Giovanni Longo, Charles Roduit, Bhaskar Saha, Andrea Volterra

Stiffness tomography is a new atomic force microscopy imaging technique that allows highlighting structures located underneath the surface of the sample. In this imaging mode, such structures are identified by investigating their mechanical properties. We ...

Wiley-Blackwell2012

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