Concept

Enveloppe virale

Publications associées (132)

An Atomistic Look into Bio-inspired Nanoparticles and their Molecular Interactions with Cells

Francesco Stellacci, Alke Fink, Pablo Campomanes Ramos, Stefano Vanni

Nanoparticles (NPs) have sizes that approach those of pathogens and they can interact with the membranes of eukaryotic cells in an analogous fashion. Typically, NPs are taken up by the cell via the plasma membrane by receptor-mediated processes and subsequ ...

SWISS CHEMICAL SOC2019

Differences in viral disinfection mechanisms as revealed by quantitative transfection of Echovirus 11 genomes

Urs von Gunten, Tamar Kohn, Jason Robert Torrey

Virus inactivation mechanisms can be elucidated by methods which measure the loss of specific virus functionality (e.g., host attachment, genome internalization, genome replication). Genome functionality is frequently assessed by PCR-based methods, which a ...

2019

Virucidal nanomaterials against influenza

Özgün Kocabiyik

Influenza affects millions of people in all parts of the world. The fact that influenza virus can spread through air increases the chance of influenza outbreaks. There are 3 to 5 million severe cases of influenza resulting in 290,000 to 650,000 deaths ever ...

EPFL2019

Virus transfer at the skin-liquid interface and its associated risks

Ana Karina Pitol Garcia

Infectious diseases are a leading cause of death across the world. One of the primary causes of infectious diseases are viruses. Since liquids are highly important in the transmission of viruses, the aims of this work are to i) quantify the transfer of vir ...

EPFL2018

Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism

Francesco Stellacci, Paulo Henrique Jacob Silva, Ahmet Bekdemir, Valeria Cagno, Emma-Rose Janecek, Samuel Thomas Jones, Marie Mueller

Viral infections kill millions yearly. Available antiviral drugs are virus-specific and active against a limited panel of human pathogens. There are broad-spectrum substances that prevent the first step of virus–cell interaction by mimicking heparan sulfat ...

2018

Detection of antimicrobial resistance-associated proteins by titanium dioxide-facilitated intact bacteria mass spectrometry

Hubert Girault, Horst Pick, Natalia Gasilova, Liang Qiao, Milica Jovic, Yingdi Zhu

Titanium dioxide-modified target plates were developed to enhance intact bacteria analysis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The plates were designed to photocatalytically destroy the bacterial envelope struct ...

2018

Broad-spectrum Antiviral Nanoparticles

Marie Müller

Viral infections affect millions of people every year, yet broad-spectrum virucidal therapies are not available. Antiviral substances in current use act on specific viral mechanisms against only a small number of viruses. Virustatic materials interfere wit ...

EPFL2017

Inhalation intake fraction of particulate matter from localized indoor emissions

Dusan Licina

Elevated exposure to airborne particulate matter is linked to deleterious health and well-being outcomes. Exposure assessment can be improved through enhanced understanding of source-receptor relationships, for example as expressed in the inhalation intake ...

2017

Oxidation-sensitive polymersomes as vaccine nanocarriers enhance humoral responses against Lassa virus envelope glycoprotein

Marcela Rincón-Restrepo, Jeffrey Alan Hubbell, Melody Swartz, Sachiko Hirosue, Clara Galan Navarro, Stefan Kunz

Lassa virus (LASV) causes severe hemorrhagic fever with high mortality, yet no vaccine currently exists. Antibodies targeting viral attachment proteins are crucial for protection against many viral infections. However, the envelope glycoprotein (GP) 1 of L ...

Academic Press Inc Elsevier Science2017

Experimental adaptation of human echovirus 11 to ultraviolet radiation leads to tolerance to disinfection and resistance to ribavirin

Tamar Kohn, Anna Carratala Ripolles, Virginie Bachmann, Jeffrey David Jensen, Qingxia Zhong, Hyunjin Shim

Ultraviolet light in the UVC range is a commonly used disinfectant to control viruses in clinical settings and water treatment. Here, we employed an experimental evolution approach to investigate the adaptation of human echovirus 11 to disinfection by UVC, ...

2017

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