Publications associées à Asthme

Neutrophils suppress tumor-infiltrating T cells in colon cancer via matrix metalloproteinase-mediated activation of TGF beta

Freddy Radtke, Nadine Fournier, George Coukos, Marc-Olivier Sauvain, Mauro Delorenzi, Amber Dawn Bowler, Markus Germann

High T-cell infiltration in colorectal cancer (CRC) correlates with a favorable disease outcome and immunotherapy response. This, however, is only observed in a small subset of CRC patients. A better understanding of the factors influencing tumor T-cell re ...

2020

Application of anti-amyloid beta immunization using encapsulated cell technology in mouse models of Alzheimer's disease

Vanessa Laversenne

Alzheimer's disease (AD) is the most common form of dementia in the elderly. AD is characterized by the deposition of two aggregated proteins: Amyloid beta (Aß) and hyperphosphorylated tau. Accumulations of these proteins are thought to be the signature ...

EPFL2019

The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation

Jacques Rougemont, Laure Menin, Nicola Harris, Mario Michael Zaiss, Ilaria Mosconi, Alessandra Piersigilli, Benjamin John Marsland, Lalit Kumar Dubey, Alexis Rapin, Luc Xavier Marie Lebon

Intestinal helminths are potent regulators of their host's immune system and can ameliorate inflammatory diseases such as allergic asthma. In the present study we have assessed whether this anti-inflammatory activity was purely intrinsic to helminths, or w ...

Elsevier2015

Thymic stromal lymphopoietin plays divergent roles in murine models of atopic and nonatopic airway inflammation

Nicola Harris, Benjamin John Marsland, Ilaria Mosconi

BackgroundThymic stromal lymphopoietin (TSLP) is a cytokine primarily produced by epithelial cells, which has been shown to be a potent inducer of T-helper 2 (Th2)-type responses. However, TSLP has pleiotropic effects upon immune cells, and although extens ...

Wiley-Blackwell2014

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

Nicola Harris, Eva Sabrina Gollwitzer, Benjamin John Marsland

Metabolites from intestinal microbiota are key determinants of host-microbe mutualism and, consequently, the health or disease of the intestinal tract. However, whether such host-microbe crosstalk influences inflammation in peripheral tissues, such as the ...

Nature Publishing Group2014

Identification of airway bacterial colonization by an electronic nose in Chronic Obstructive Pulmonary Disease

Background: Airway bacterial colonization by potentially pathogenic microorganisms occurs in a proportion of patients with Chronic Obstructive Pulmonary Disease (COPD). It increases airway inflammation and influences outcomes negatively. Yet, its diagnosis ...

Elsevier2014

Transcription factor ROR alpha is critical for nuocyte development

Freddy Radtke, Ute Koch

Nuocytes are essential in innate type 2 immunity and contribute to the exacerbation of asthma responses. Here we found that nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, which indicates they are distinct, previously ...

2012

Dysregulation of Allergic Airway Inflammation in the Absence of Microbial Colonization

Nicola Harris, Benjamin John Marsland, Tina Herbst

RATIONALE: The incidence of allergic disorders is increasing in developed countries and has been associated with reduced exposure to microbes and alterations in the commensal bacterial flora. OBJECTIVES: To ascertain the relevance of commensal bacteria upo ...

2011

Effects of dynamic compression on lentiviral transduction in an in vitro airway wall model

Melody Swartz, Alice Anna Tomei

Asthmatic patients are more susceptible to viral infection, and we asked whether dynamic strain on the airway wall (such as that associated with bronchoconstriction) would influence the rate of viral infection of the epithelial and subepithelial cells. To ...

2008

Extracellular Matrix Remodeling by Dynamic Strain in a 3D Tissue Engineered Human Airway Wall Model

Melody Swartz

Airway wall remodeling is a hallmark of asthma, characterized by subepithelial thickening and extracellular matrix (ECM) remodeling. Mechanical stress due to hyperresponsive smooth muscle cells may contribute to this remodeling, but its extent and relevanc ...

2006