Concept
Immunité croisée
Publications associées (25)
Targeting molecular surfaces to engineer novel protein-based immunogens and inhibitors
Proteins are the basic building blocks necessary for the operation and regulation of virtually all functions in living organisms. Over millions of years, evolution has created a vast repertoire of proteins finely tuned to execute their biological functions ...
EPFL2022On the exploration of novel methodological approaches for immunogen design: case studies in influenza and hepatitis C
Proteins are fundamental components in biological systems and crucial for a variety of biological functions. Over the last decades, significant progress in structural biology has facilitated the study of proteins and their interactions with molecular partn ...
EPFL2021Interbacterial competition and anti‐predatory behavior of environmental Vibrio cholerae strains
Melanie Blokesch, Natalia Carolina Drebes Dorr
Vibrio cholerae isolates responsible for cholera pandemics represent only a small portion of the diverse strains belonging to this species. Indeed, most V. cholerae are encountered in aquatic environments. To better understand the emergence of pandemic lin ...
2020Expanding beyond the natural protein repertoire to engineer targeted vaccines and diagnostics
Proteins have evolved over millions of years to carry out the vast majority of biological functions that are fundamental to life. Their three-dimensional structures and functions have been in the focus of biomedical research for many decades, and substanti ...
EPFL2019A ligand-based system for receptor-specific delivery of proteins
Gene delivery using vector or viral-based methods is often limited by technical and safety barriers. A promising alternative that circumvents these shortcomings is the direct delivery of proteins into cells. Here we introduce a non-viral, ligand-mediated p ...
Springer2019Human bone progenitor cells for clinical application: what kind of immune reaction does fetal xenograft tissue trigger in immuno-competent rats?
Dominique Pioletti, Lee Ann Laurent-Applegate, Tanja Cloé Hausherr
The potential of human fetal bone cells for successful bone regeneration has been shown in vivo. In particular, it has been demonstrated that the seeding of these cells in porous poly-(L-lactic acid)/ ß-tricalcium phosphate scaffolds improved the bone form ...
Cognizant Communication Corp2017Preparation and Characterization of Stable -Synuclein Lipoprotein Particles
Multiple neurodegenerative diseases are caused by the aggregation of the human -Synuclein (-Syn) protein. -Syn possesses high structural plasticity and the capability of interacting with membranes. Both features are not only essential for its physiological ...
American Society for Biochemistry & Molecular Biology (ASBMB)2016