Concept
Mycobacterium leprae
Publications associées (117)
Investigating the composition and recruitment of the mycobacterial ImuA'-ImuB-DnaE2 mutasome
John McKinney, Neeraj Dhar, Zela Alexandria-Mae Martin
A DNA damage-inducible mutagenic gene cassette has been implicated in the emergence of drug resistance in Mycobacterium tuberculosis during anti-tuberculosis (TB) chemotherapy. However, the molecular composition and operation of the encoded 'mycobacterial ...
Cambridge2023Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania
In settings with high tuberculosis (TB) endemicity, distinct genotypes of the Mycobacterium tuberculosis complex (MTBC) often differ in prevalence. However, the factors leading to these differences remain poorly understood. Here we studied the MTBC populat ...
PUBLIC LIBRARY SCIENCE2023Development and validation of a multiplex real-time qPCR assay using GMP-grade reagents for leprosy diagnosis
Stewart Cole, Charlotte Avanzi, Thyago Leal Calvo
Author summaryLeprosy is a chronic dermato-neurological disease caused by Mycobacterium leprae, an obligate intracellular bacterium. Diagnosis of leprosy often relies on skin examinations for clinical signs, bacilli staining from skin smears and invasive s ...
PUBLIC LIBRARY SCIENCE2022Gene expression patterns associated with multidrug therapy in multibacillary leprosy
Stewart Cole, Andrej Benjak, Charlotte Avanzi, Philippe Busso, Thyago Leal Calvo
Multidrug therapy (MDT) has been successfully used in the treatment of leprosy. However, although patients are cured after the completion of MDT, leprosy reactions, permanent disability, and occasional relapse/reinfection are frequently observed in patient ...
FRONTIERS MEDIA SA2022A new paradigm for leprosy diagnosis based on host gene expression
Stewart Cole, Andrej Benjak, Charlotte Avanzi, Philippe Busso, Thyago Leal Calvo
Author summary Despite effective treatment, leprosy is still a significant public health issue in more than 120 countries, with more than 200 000 new cases yearly. The disease is caused mainly by Mycobacterium leprae, a slow-growing bacillus still uncultiv ...
PUBLIC LIBRARY SCIENCE2021Mycobacterium leprae diversity and population dynamics in medieval Europe from novel ancient genomes
Stewart Cole, Charlotte Avanzi, Philippe Busso
Background Hansen's disease (leprosy), widespread in medieval Europe, is today mainly prevalent in tropical and subtropical regions with around 200,000 new cases reported annually. Despite its long history and appearance in historical records, its origins ...
BMC2021Genomic Characterization ofMycobacterium lepraeto Explore Transmission Patterns Identifies New Subtype in Bangladesh
Stewart Cole, Andrej Benjak, Charlotte Avanzi
Mycobacterium leprae, the causative agent of leprosy, is an unculturable bacterium with a considerably reduced genome (3.27 Mb) compared to homologues mycobacteria from the same ancestry. In 2001, the genome ofM. lepraewas first described and subsequently ...
FRONTIERS MEDIA SA2020Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros
Stewart Cole, Andrej Benjak, Charlotte Avanzi, Philippe Busso, Pushpendra Singh, Thyago Leal Calvo
Human settlement of Madagascar traces back to the beginning of the first millennium with the arrival of Austronesians from Southeast Asia, followed by migrations from Africa and the Middle East. Remains of these different cultural, genetic, and linguistic ...
2020Emergence of Mycobacterium leprae Rifampin Resistance Evaluated by Whole-Genome Sequencing after 48 Years of Irregular Treatment
Stewart Cole, Andrej Benjak, Charlotte Avanzi, Philippe Busso
A case of Mycobacterium leprae rifampin resistance after irregular antile- prosy treatments since 1971 is reported. Whole-genome sequencing from four longi- tudinal samples indicated relapse due to acquired rifampin resistance and not to re- infection with ...
AMER SOC MICROBIOLOGY2020Polarly Localized EccE(1) Is Required for ESX-1 Function and Stabilization of ESX-1 Membrane Proteins in Mycobacterium tuberculosis
Stewart Cole, Claudia Sala, Ming Zhang, Jérémie Piton, Paloma Julia Soler Arnedo
Mycobacterium tuberculosis is a slow-growing intracellular bacterium with the ability to induce host cell death and persist indefinitely in the human body. This pathogen uses the specialized ESX-1 secretion system to secrete virulence factors and potent im ...
AMER SOC MICROBIOLOGY2020