Publications associées à Monocyte

Sirt6 deletion in bone marrow-derived cells increases atherosclerosis - Central role of macrophage scavenger receptor 1

Johan Auwerx, Matthias Alexander Sokrates Stein, Julien Weber, Tasneem Arsiwala

Aims: Sirtuin 6 (Sirt6) is a NAD(+)-dependent deacetylase that plays a key role in DNA repair, inflammation and lipid regulation. Sirt6-null mice show severe metabolic defects and accelerated aging. Macrophage-foam cell formation via scavenger receptors is ...

2020

TGR5/Cathepsin E signaling regulates macrophage innate immune activation in liver ischemia and reperfusion injury

Johan Auwerx, Kristina Schoonjans, Qi Wang

The role and underlying mechanism of plasma membrane-bound G protein-coupled bile acid receptor (TGR5) in regulating macrophage innate immune activation during liver ischemia and reperfusion (IR) injury remains largely unclear. Here, we demonstrated that T ...

2020

Two Nimrod receptors, NimC1 and Eater, synergistically contribute to bacterial phagocytosis in Drosophila melanogaster

Bruno Lemaitre, Jan Paul Dudzic, Elodie Julie Virginie Ramond, Andrew Jonathan Bretscher, Claudia Melcarne

Eater and NimC1 are transmembrane receptors of the Drosophila Nimrod family, specifically expressed in haemocytes, the insect blood cells. Previous ex vivo and in vivoRNAi studies have pointed to their role in the phagocytosis of bacteria. Here, we have cr ...

WILEY2019

House dust mite drives proinflammatory eicosanoid reprogramming and macrophage effector functions

Nicola Harris, Julia Esser-von Bieren, Tiffany Babette Angélique Bouchery

Background Eicosanoid lipid mediators play key roles in type 2 immune responses, for example in allergy and asthma. Macrophages represent major producers of eicosanoids and they are key effector cells of type 2 immunity. We aimed to comprehensively track e ...

WILEY2019

Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles

Francesco Stellacci, Ye Yang, Ahmet Bekdemir

We sought to develop a nanoparticle vehicle that could efficiently deliver small molecule drugs to target lymphocyte populations. The synthesized amphiphilic organic ligand-protected gold nanoparticles (amph-NPs) were capable of sequestering large payloads ...

2019

T cell–induced CSF1 promotes melanoma resistance to PD1 blockade

Michele De Palma, George Coukos, Krisztian Homicsko, Sina Nassiri, Natacha Anne-Sophie Bordry, Esther Danenberg, Laure Tillé, Christophe Martignier

Colony-stimulating factor 1 (CSF1) is a key regulator of monocyte/macrophage differentiation that sustains the protumorigenic functions of tumor-associated macrophages (TAMs). We show that CSF1 is expressed in human melanoma, and patients with metastatic m ...

2018

Absence of specific alternatively spliced exon of CD44 in macrophages prevents colitis

Ulrich Hoffmann

CD44 is a transmembrane molecule appearing in numerous isoforms generated by insertions of alternatively spliced variant exons (CD44v) and having various binding partners. CD44v7 on T cells was proposed to promote colitis by preventing T-cell apoptosis. He ...

NATURE PUBLISHING GROUP2018

Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands

Freddy Radtke, Ute Koch

Alloimmune T cell responses induce graft-versus-host disease (GVHD), a serious complication of allogeneic bone marrow transplantation (allo-BMT). Although Notch signaling mediated by Delta-like 1/4 (DLL1/4) Notch ligands has emerged as a major regulator of ...

Amer Soc Clinical Investigation Inc2017

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Monocyte

Sirt6 deletion in bone marrow-derived cells increases atherosclerosis - Central role of macrophage scavenger receptor 1

Role of Nimrod receptors in the Drosophila melanogaster cellular immune response

TGR5/Cathepsin E signaling regulates macrophage innate immune activation in liver ischemia and reperfusion injury

Two Nimrod receptors, NimC1 and Eater, synergistically contribute to bacterial phagocytosis in Drosophila melanogaster

House dust mite drives proinflammatory eicosanoid reprogramming and macrophage effector functions

Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles

The pro-apoptotic effect of a Terpene-rich Annona cherimola leaf extract on leukemic cell lines

T cell–induced CSF1 promotes melanoma resistance to PD1 blockade

Absence of specific alternatively spliced exon of CD44 in macrophages prevents colitis

Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands

Graph Chatbot

Chattez avec Graph Search

Sirt6 deletion in bone marrow-derived cells increases atherosclerosis - Central role of macrophage scavenger receptor 1

Two Nimrod receptors, NimC1 and Eater, synergistically contribute to bacterial phagocytosis in Drosophila melanogaster

Role of Nimrod receptors in the Drosophila melanogaster cellular immune response

Absence of specific alternatively spliced exon of CD44 in macrophages prevents colitis

TGR5/Cathepsin E signaling regulates macrophage innate immune activation in liver ischemia and reperfusion injury

House dust mite drives proinflammatory eicosanoid reprogramming and macrophage effector functions

Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles

T cell–induced CSF1 promotes melanoma resistance to PD1 blockade

Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands

The pro-apoptotic effect of a Terpene-rich Annona cherimola leaf extract on leukemic cell lines