Publications associées à Fitness culture

Enriching the Computational Toolbox for Organocatalysis

Organocatalysis has evolved significantly over the last decades, becoming a pillar of synthetic chemistry, but traditional theoretical approaches based on quantum mechanical computations to investigate reaction mechanisms and provide rationalizations of ca ...

EPFL2023

Genetic Algorithms for the Discovery of Homogeneous Catalysts

Rubén Laplaza Solanas, Anne-Clémence Corminboeuf, Puck Elisabeth van Gerwen, Alexandre Alain Schöpfer, Simone Gallarati

In this account, we discuss the use of genetic algorithms in the inverse design process of homogeneous catalysts for chemical transformations. We describe the main components of evolutionary experiments, specifically the nature of the fitness function to o ...

2023

Understanding intergenerational fitness tracking practices: 12 suggestions for design

Pearl Pu Faltings

The paper presents a qualitative study to explore the use of fitness trackers and their social functions in intergenerational settings. The study covered three phases of semi-structured interviews with older and younger adults during individual and interge ...

SPRINGERNATURE2022

Transient vitamin B5 starving improves mammalian cell homeostasis and protein production

Nicolas Mermod

Maintaining a metabolic steady state is essential for an organism's fitness and survival when confronted with environmental stress, and metabolic imbalance can be reversed by exposing the organism to fasting. Here, we attempted to apply this physiological ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2020

The upper limit of cardiorespiratory fitness associated with longevity: an update

Johannes Burtscher

In 2013, mortality reductions with improving cardiorespiratory fitness (CRF) have been suggested to persist until 13 METs. More recently, accumulating evidence from large-scale studies suggests that mortality from all causes decreases with increasing CRF l ...

2019

On the (un) predictability of a large intragenic fitness landscape

Jeffrey David Jensen, Claudia Bank, Sebastian Matuszewski

The study of fitness landscapes, which aims at mapping genotypes to fitness, is receiving ever-increasing attention. Novel experimental approaches combined with next-generation sequencing (NGS) methods enable accurate and extensive studies of the fitness e ...

National Academy of Sciences2016

Type 5 adenylyl cyclase disruption leads to enhanced exercise performance

Johan Auwerx, Laurent Mouchiroud, Richardus Houtkooper, Jie Zhang

The most important physiological mechanism mediating enhanced exercise performance is increased sympathetic, beta adrenergic receptor (beta-AR), and adenylyl cyclase (AC) activity. This is the first report of decreased AC activity mediating increased exerc ...

Wiley-Blackwell2015

Artificial Evolution by Viability Rather Than Competition

Dario Floreano, Andrea Maesani, Pradeep Ruben Fernando

Evolutionary algorithms are widespread heuristic methods inspired by natural evolution to solve difficult problems for which analytical approaches are not suitable. In many domains experimenters are not only interested in discovering optimal solutions, but ...

Public Library of Science2014

Differences in the Concept of Fitness Between Artificial Evolution and Natural Selection

Dario Floreano, Laurent Keller, Pawel Lichocki

Evolutionary algorithms were proposed to automatically find solutions to computational problems, much like evolution discovers new adaptive traits. Lately, they have been used to address challenging questions about the evolution of modularity, the genetic ...

The MIT Press2012

A Quantitative Test of Hamilton's Rule for the Evolution of Altruism

Dario Floreano, Laurent Keller, Markus Waibel

The evolution of altruism is a fundamental and enduring puzzle in biology. In a seminal paper Hamilton showed that altruism can be selected for when rb − c>0, where c is the fitness cost to the altruist, b is the fitness benefit to the beneficiary, and r i ...

Public Library of Science2011