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The molecular mechanisms that govern bone and joint formation are complex, involving an integrated network of signaling pathways and gene regulators. We investigated the role of Hox genes, which are known to specify individual segments of the skeleton, in ...
American Society for Clinical Investigation2010
Adult stem cells hold many promises for future clinical applications and regenerative medicine. The haematopoietic stem cell (HSC) is the best-characterized somatic stem cell so far, but in vitro expansion has been unsuccessful, limiting the future therape ...
Objective. The objective of the present study was to develop a numerical model of the shoulder able to quantify the influence of the shape of the humeral head on the stress distribution in the scapula. The subsequent objective was to apply the model to the ...
Robustness to formation geological heterogeneities of the limited entry technique for multi-stage fracturing of horizontal wells is investigated. It is necessary to simulate the complete process of initiation and propagation of multiple hydraulic fractures ...
The initial stability of cementless femoral components is crucial for the long-term success of total hip arthroplasty. This has been reported in animal and clinical studies. Until now, the stability was evaluated by the measurement of relative micromotion ...
Elsevier2012
The topography of freshly fractured bovine and human bone surfaces was determined by the use of atomic force microscopy (AFM). Fracture surfaces from both kinds of samples exhibited complex landscapes formed by hydroxyapatite mineral platelets with lateral ...
2007
Using an atomic force microscope and a surface force apparatus, we measured the surface coverage, adhesion, and mechanical properties of layers of osteopontin (OPN), a phosphoprotein of the human bones, adsorbed on mica. OPN is believed to connect minerali ...
