Concept

Genotype–phenotype distinction

Publications associées (9)

Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania

In settings with high tuberculosis (TB) endemicity, distinct genotypes of the Mycobacterium tuberculosis complex (MTBC) often differ in prevalence. However, the factors leading to these differences remain poorly understood. Here we studied the MTBC populat ...

PUBLIC LIBRARY SCIENCE2023

A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes

Kathryn Hess Bellwald, Lida Kanari, Martina Scolamiero

Environmental cues influence the highly dynamic morphology of microglia. Strategies to characterize these changes usually involve user-selected morphometric features, which preclude the identification of a spectrum of context-dependent morphological phenot ...

NATURE PORTFOLIO2022

Linking a mutation to survival in wild mice

Jeffrey David Jensen, Matthieu Foll, Susanne Petra Pfeifer, Stefan Jean Laurent

Adaptive evolution in new or changing environments can be difficult to predict because the functional connections between genotype, phenotype, and fitness are complex. Here, we make these explicit connections by combining field and laboratory experiments i ...

AMER ASSOC ADVANCEMENT SCIENCE2019

Plastic and genetic responses of a common sedge to warming have contrasting effects on carbon cycle processes

Luca Bragazza, Constant Signarbieux, Richard David Bardgett, Thomas William Nicholas Walker

Climate warming affects plant physiology through genetic adaptation and phenotypic plasticity, but little is known about how these mechanisms influence ecosystem processes. We used three elevation gradients and a reciprocal transplant experiment to show th ...

2019

Can multi-generational exposure to ocean warming and acidification lead to the adaptation of life-history and physiology in a marine metazoan?

Emma Mary Gibbin, Félix Christen

Ocean warming and acidification are concomitant global drivers that are currently threatening the survival of marine organisms. How species will respond to these changes depends on their capacity for plastic and adaptive responses. Little is known about th ...

Company Of Biologists Ltd2016

Distinguishing knowledge integration gains in evolution education through concept map network analysis

Beat Adrian Schwendimann

Understanding how evolutionary changes happen requires connecting genotype and phenotype level concepts. This study uses a form of concept map, called Knowledge Integration Map (KIM), as a learning and assessment tool to support and assess connecting conce ...

2016

Catch Me if You Can: Adaptation from Standing Genetic Variation to a Moving Phenotypic Optimum

Sebastian Matuszewski

Adaptation lies at the heart of Darwinian evolution. Accordingly, numerous studies have tried to provide a formal framework for the description of the adaptive process. Of these, two complementary modeling approaches have emerged: While so-called adaptive- ...

2015

Mapping biological ideas: Concept maps as knowledge integration tools for evolution education

Beat Adrian Schwendimann

Many students leave school with a fragmented understanding of biology that does not allow them to connect their ideas to their everyday lives (Wandersee, 1989; Mintzes, Wandersee, & Novak, 1998; Mintzes, Wandersee, & Novak, 2000a). Understanding evolution ...

University of California, Berkeley2011

The evolution of mycobacterial pathogenicity: clues from comparative genomics

Stewart Cole

Comparative genomics, and related technologies, are helping to unravel the molecular basis of the pathogenesis, host range, evolution and phenotypic differences of the slow-growing mycobacteria. In the highly conserved Mycobacterium tuberculosis complex, w ...

2001

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