Concept

Herpes simplex virus

Publications associées (71)

Actively transporting virus like analytes with optofluidics for rapid and ultrasensitive biodetection

Hatice Altug, Arif Engin Cetin, Min Huang

Effective analyte delivery is essential to achieve rapid and sensitive biodetection systems. In this article, we present an actively controlled fluidic system integrated with a suspended plasmonic nanohole sensor to achieve superior analyte delivery effici ...

2013

Vaccinia Virus Entry Is Followed by Core Activation and Proteasome-Mediated Release of the Immunomodulatory Effector VH1 from Lateral Bodies

Henning Paul-Julius Stahlberg, Lucia Reh

Host cell entry of vaccinia virus, the prototypic poxvirus, involves a membrane fusion event delivering the viral core and two proteinaceous lateral bodies (LBs) into the cytosol. Uncoating of viral cores is poorly characterized, and the composition and fu ...

Elsevier BV2013

RNAi Screening Reveals Proteasome- and Cullin3-Dependent Stages in Vaccinia Virus Infection

Henning Paul-Julius Stahlberg

A two-step, automated, high-throughput RNAi silencing screen was used to identify host cell factors required during vaccinia virus infection. Validation and analysis of clustered hits revealed previously unknown processes during virus entry, including a me ...

Elsevier BV2012

Simplex-Coded BOTDA Sensor Over 120-km SMF With 1-m Spatial Resolution Assisted by Optimized Bidirectional Raman Amplification

Marcelo Alfonso Soto Hernandez

Bidirectional low-noise Raman amplification and simplex coding based on the return-to-zero modulation format are optimized through numerical simulations for long-range Brillouin optical time-domain analysis sensing. Experimental results are reported on sen ...

2012

Optimization of a DPP-BOTDA sensor with 25 cm spatial resolution over 60 km standard single-mode fiber using Simplex codes and optical pre-amplification

Marcelo Alfonso Soto Hernandez

Sub-meter distributed optical fiber sensing based on Brillouin optical time-domain analysis with differential pulse-width pairs (DPP-BOTDA) is combined with the use of optical pre-amplification and pulse coding. In order to provide significant measurement ...

Optical Society of America2012

UV radiation induces genome-mediated, site-specific cleavage in viral protein

Tamar Kohn, Yury Tsybin, Laure Menin, Krista Rule Wigginton, Michele Cascella, Hisham Ben Hamidane, Anne Thérèse Sigstam

Much research has been dedicated to understanding the molecular basis of UV damage to biomolecules, yet many questions remain regarding the specific pathways involved. Here we describe a genome-mediated mechanism that causes sitespecific virus protein clea ...

2012

Virus inactivation mechanisms: impact of disinfectants on virus function and structural integrity

Tamar Kohn, Krista Rule Wigginton, Brian Pecson, Anne Thérèse Sigstam, Franziska Sara Bosshard

Oxidative processes are often harnessed as tools for pathogen disinfection. Although the pathways responsible for bacterial inactivation with various biocides are fairly well understood, virus inactivation mechanisms are often contradictory or equivocal. I ...

Amer Chemical Soc2012

A framework for using quantitative PCR as a non-culture based method to estimate virus infectivity

Tamar Kohn, Martin Ackermann, Brian Pecson

Measuring the efficiency of virus disinfection with quantitative PCR (qPCR) has been criticized as inadequate due to the production of false-positive signals. Such a claim, however, presupposes an understanding of the theoretical qPCR response. Many studie ...

2011

Characterization of glycoprotein E C-End of West Nile virus and evaluation of its interaction force with alpha V beta 3 integrin as putative cellular receptor

Giovanni Dietler

Recombinant polypeptide containing the 260-466 amino acid sequence of West Nile virus (WNV) strain LEIV-Vlg99-27889-human glycoprotein E (gpE, E260-466) was constructed. Immunochemical similarity between the E260-466 and gpE of WNV was proven by enzyme imm ...

2010

Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice

Nicola Harris

The innate immune response plays an essential role in the prevention of early viral dissemination. We used the lymphocytic choriomeningitis virus model system to analyze the role of tissue macrophages/Kupffer cells in this process. Our findings demonstrate ...

2010

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