Polyvinylpyrrolidone

Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer compound made from the monomer N-vinylpyrrolidone. PVP is available in a range of molecular weights and related viscosities, and can be selected according to the desired application properties. It is used as a binder in many pharmaceutical tablets; it simply passes through the body when taken orally. PVP added to iodine forms a complex called povidone-iodine that possesses disinfectant properties. This complex is used in various products such as solutions, ointment, pessaries, liquid soaps, and surgical scrubs. It is sold under the trade names Pyodine and Betadine, among others. It is used in pleurodesis (fusion of the pleura because of incessant pleural effusions). For this purpose, povidone iodine is as effective and safe as talc, and may be preferred because of easy availability and low cost. PVP is used in some contact lenses and their packaging solutions. It reduces friction, thus acting as a lubricant, or wetting agent, built into the lens. Examples of this use include Bausch & Lomb's Ultra contact lenses with MoistureSeal Technology and Air Optix contact lens packaging solution (as an ingredient called "copolymer 845"). PVP is used as a lubricant in some eye drops, e.g. Bausch & Lomb's Soothe. PVP was used as a plasma volume expander for trauma victims after the 1950s. It is not preferred as volume expander due to its ability to provoke histamine release and also interfere with blood grouping. Autopsies have found that crospovidone (PVPP) contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption. The long-term effects of crospovidone or povidone within the lung are unknown.