Concept

Dépression synaptique à long terme

Publications associées (353)

Rapid optimisation of a lactate biosensor design using soft probes scanning electrochemical microscopy

Hubert Girault, Andreas Stephan Lesch, Fernando Cortes Salazar

We report the mapping of biocatalytically active surfaces, particularly on an express search for optimal immobilization conditions of the enzyme lactate oxidase by means of scanning electrochemical microscopy (SECM). With this aim, soft stylus SECM probes ...

Elsevier2014

Role of Protein Kinase C and Munc18-1 in a Presynaptic Form of Plasticity, Post-tetanic Potentiation

Özgür Genç

Neurons are arranged in networks in which they communicate between each other by the means of synapses. Synaptic transmission can undergo activity-dependent and short-lived changes in strength, known as short-term synaptic plasticity. Short-term plasticity ...

EPFL2013

Network Activity and Plasticity

Vincent Delattre

The cortex must maintain balanced levels of neural activity to correctly integrate inputs and to provide contextually meaningful outputs. Neuronal excitation is counterbalanced by various forms of inhibition such as spike frequency adaptation, short- and l ...

EPFL2013

Medium-to long-term frequency stability of high-performance CW double-resonance Rb standard

Anja Skrivervik, Francesco Merli, Camillo Stefanucci

We present the short-term noise budget and metro-logical studies on the medium-to long-term stability of our Rb standard. Our clock exhibits a short-term stability of ∼ 1.4×10-13 τ-1/2. The dependance of microwave power shift on light intensity, and the po ...

IEEE2013

Matched Pre- and Post-Synaptic Changes Underlie Synaptic Plasticity over Long Time Scales

Henry Markram, Jean-Vincent Le Bé

Modifications of synaptic efficacies are considered essential for learning and memory. However, it is not known how the underlying functional components of synaptic transmission change over long time scales. To address this question, we studied cortical sy ...

Soc Neuroscience2013

Altered Synaptic Dynamics during Normal Brain Aging

Graham Knott, Bohumil Maco

What is the neuroanatomical basis for the decline in brain function that occurs during normal aging? Previous postmortem studies have blamed it on a reduction in spine density, though results remain controversial and spine dynamics were not assessed. We us ...

Soc Neuroscience2013

Models of Reward-Modulated Spike-Timing-Dependent Plasticity

Nicolas Frémaux

How do animals learn to repeat behaviors that lead to the obtention of food or other “rewarding” objects? As a biologically plausible paradigm for learning in spiking neural networks, spike-timing dependent plasticity (STDP) has been shown to perform well ...

EPFL2013

Increased axonal bouton dynamics in the aging mouse cortex

Graham Knott, Bohumil Maco, Ge Gao

Aging is a major risk factor for many neurological diseases and is associated with mild cognitive decline. Previous studies suggest that aging is accompanied by reduced synapse number and synaptic plasticity in specific brain regions. However, most studies ...

National Academy of Sciences2013

Long-Term Development of Thermophysical and Mechanical Properties of Cold-Curing Structural Adhesives Due to Post-Curing

Thomas Keller, Anastasios Vassilopoulos, Julia De Castro San Roman Fest, Omar Moussa

The long-term changes in the thermophysical and mechanical properties of a cold-curing structural epoxy adhesive were investigated by accelerating the curing reaction by post-curing at elevated temperatures. Experimental data concerning the glass transitio ...

Wiley-Blackwell2013

Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo

Wulfram Gerstner

Action Potential (APs) patterns of sensory cortex neurons encode a variety of stimulus features, but how can a neuron change the feature to which it responds? Here, we show that in vivo a spike-timing-dependent plasticity (STDP) protocol-consisting of pair ...

Elife Sciences Publications Ltd2013

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