Concept

Néocortex

Publications associées (129)

Frequency-dependent disynaptic inhibition in the pyramidal network: a ubiquitous pathway in the developing rat neocortex

Henry Markram, Rodrigo de Campos Perin, Thomas Berger, Gilad Silberberg

The general structure of the mammalian neocortex is remarkably similar across different cortical areas. Despite certain cytoarchitectural specializations and deviations from the general blueprint, the principal organization of the neocortex is relatively u ...

2009

Properties of neocortical microcircuits

Thomas Berger

The mammalian neocortex is one of the most complex brain areas, integrating all sensory modalities and allowing the animal to perform high level cognitive operations. Despite some cytoarchitectural specializations, the general neocortical structure is rema ...

EPFL2009

Congenital heart disease affects local gyrification in 22q11.2 deletion syndrome

Jean-Philippe Thiran, Meritxell Bach Cuadra, Marie Schaer

22q11.2 deletion syndrome (22q11.2DS) is a common genetic condition associated with cognitive and learning impairments. In this study, we applied a threedimensional method for quantifying gyrification at thousands of points over the cortical surface to ima ...

Wiley-Blackwell2009

Genetic manipulation, whole-cell recordings and functional imaging of the sensorimotor cortex of behaving mice

Carl Petersen

Sensory processing, sensorimotor integration and motor control are amongst the most basic functions of the brain and yet our understanding of how the underlying neuronal networks operate and contribute to behaviour is very limited. The relative simplicity ...

2009

Global brain connectivity analysis by diffusion MR tractography

Xavier Gigandet

The human cerebral cortex consists of approximately 1010 neurons that are organized into a complex network of local circuits and long-range connections. During the past years there has been an increasing interest from the neuro-scientific community towards ...

EPFL2009

Fixing the location and dimensions of functional neocortical columns

Henry Markram

The quest to understand the way in which neurons interconnect to form circuits that function as a unit began when Ramon y Cajal concluded that axo-dendritic apposition were too conspicuous to be incidental and proposed that two neurons must be communicatin ...

2008

Genes, Brain Development and Psychiatric Phenotypes in Velo-Cardio-Facial Syndrome

Marie Schaer

Velo-cardio-facial syndrome (VCFS) has been in the focus of intensive research over the last 15 years. The syndrome represents a homogeneous model for studying the effect of a decreased dosage of genes on the development of brain structure and function and ...

2008

Identifying, tabulating, and analyzing contacts between branched neuron morphologies

Henry Markram

Simulating neural tissue requires the construction of models of the anatomical structure and physiological function of neural microcircuitry. The Blue Brain Project is simulating the microcircuitry of a neocortical column with very high structural and phys ...

2008

Hyperconnectivity of Local Neocortical Microcircuitry Induced by Prenatal Exposure to Valproic Acid

Henry Markram, Gilad Silberberg, Tania Rinaldi

Exposure to valproic acid (VPA) during embryogenesis can cause several teratogenic effects, including developmental delays and in particular autism in humans if exposure occurs during the third week of gestation. We examined the postnatal effects of embryo ...

Oxford University Press2008

A Surface-based approach to Quantify Local Cortical Gyrification

Jean-Philippe Thiran, Meritxell Bach Cuadra, Marie Schaer, François Lazeyras

The high complexity of cortical convolutions in humans remains a mystery for both engineers to measure and compare it, and for biologists to understand it. We developed a method for the quantification of the cortical area allowed by the process of folding. ...

2008

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