Concept

Thrombolyse

Publications associées (15)

A variant of t-PA (T103N, KHRR 296-299 AAAA) that, by bolus, has increased potency and decreased systemic activation of plasminogen

In the accompanying paper, we reported that the properties of decreased plasma clearance rate, increased fibrin specificity, and resistance to inactivation by PAI-1 could be effectively combined in the t-PA variant T103N, KHRR 296-299 AAAA. In the current ...

1993

Evidence for a role in thrombus stabilization for thromboxane A2 in human platelet deposition on collagen

Jeffrey Alan Hubbell

The role of thromboxane A2 (TxA2) in platelet deposition onto collagen was studied in flowing whole heparinized human blood in vitro by using a cyclooxygenase inhibitor, aspirin, and a TxA2 receptor antagonist, GR32191B. Previous studies have demonstrated ...

1992

A region of tissue plasminogen activator that affects plasminogen activation differentially with various fibrin(ogen)-related stimulators

Florian Maria Wurm

The dissolution of blood clots by plasmin is normally initiated in vivo by the activation of plasminogen to plasmin through the activity of tissue plasminogen activator (t-PA). The rate of plasminogen activation can be stimulated several orders of magnitud ...

1992

High resolution analysis of functional determinants on human tissue-type plasminogen activator

Florian Maria Wurm

Sixty-four variants of human tissue-type plasminogen activator (tPA) were produced using recombinant DNA techniques. Charged residues were converted to alanine in clusters of from one to four changes per variant; these clusters spanned all the domains of t ...

1991

Tissue-type plasminogen activator antigen and plasminogen activator inhibitor in diabetes mellitus

Johan Auwerx

Parameters of fibrinolysis, including euglobulin fibrinolytic activity, tissue-type plasminogen activator (t-PA) antigen, plasminogen activator inhibitor (PA-inhibitor) activity, and plasmin-alpha 2-antiplasmin complex (PAP) were studied in 62 patients (35 ...

1988

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