Publications associées à Antiviral

HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

Jacques Fellay, Christian Hammer, Daniel Sauter

Many viral pathogens target innate sensing cascades and/or cellular transcription factors to suppress antiviral immune responses. Here, we show that the accessory viral protein U (Vpu) of HIV-1 exerts broad immunosuppressive effects by inhibiting activatio ...

2019

Breaking the Fourth Wall: Modulating Quaternary Associations for Protein Regulation and Drug Discovery

Yimon Aye, Bokyoung Kim

Protein-protein interactions (PPIs) are an effective means to orchestrate intricate biological processes required to sustain life. Approximately 650000 PPIs underlie the human interactome; thus underscoring its complexity and the manifold signaling outputs ...

WILEY-V C H VERLAG GMBH2019

A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1

Paul Joseph Dyson, Laure Menin, Wee Han Ang

Cisplatin [cis-diamminedichloroplatinum(II) (cis-DDP)] is one of the most successful anticancer agents effective against a wide range of solid tumors. However, its use is restricted by side effects and/or by intrinsic or acquired drug resistance. Here, we ...

PNAS2019

Two-photon triggered photorelease of caged compounds from multifunctional harmonic nanoparticles

Sandrine Gerber, Laure Menin, Daniel Ortiz Trujillo, Jérémy Vuilleumier, Raphaël Jovita De Matos, Luigi Bonacina

The design of stimuli-responsive nanocarriers has raised much attention to achieve higher local concentration of therapeutics and mitigate the appearance of drug resistance. The combination of imaging properties and controlled photorelease of active molecu ...

2019

Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism

Francesco Stellacci, Paulo Henrique Jacob Silva, Ahmet Bekdemir, Valeria Cagno, Emma-Rose Janecek, Samuel Thomas Jones, Marie Mueller

Viral infections kill millions yearly. Available antiviral drugs are virus-specific and active against a limited panel of human pathogens. There are broad-spectrum substances that prevent the first step of virus–cell interaction by mimicking heparan sulfat ...

2018

Optimized Background Regimen for Treatment of Active Tuberculosis with the Next-Generation Benzothiazinone Macozinone (PBTZ169)

Stewart Cole, Anthony Vocat, Shi-Yan Caroline Foo, Andréanne Lupien, Jean-Yves Gillon

The efficacy of the standardized four-drug regimen (comprising isoniazid, rifampin, pyrazinamide, and ethambutol) for the treatment of tuberculosis (TB) is menaced by the emergence of multidrug-resistant (MDR) and extensively drugresistant (XDR) strains of ...

AMER SOC MICROBIOLOGY2018

Drug Repurposing Approach Identifies a Synergistic Drug Combination of an Antifungal Agent and an Experimental Organometallic Drug for Melanoma Treatment

Paul Joseph Dyson, Tina Riedel, Olivier Pierre Zava

By screening a drug library comprising FDA approved compounds, we discovered a potent interaction between the antifungal agent haloprogin and the experimental organometallic drug RAPTA-T, to synergistically induce cancer cell killing. The combination of th ...

2018

The Combined Effect of Oseltamivir and Favipiravir on Influenza A Virus Evolution

Jeffrey David Jensen, Claudia Bank, Sebastian Matuszewski, Nicky Louise Ormond

Influenza virus inflicts a heavy death toll annually and resistance to existing antiviral drugs has generated interest in the development of agents with novel mechanisms of action. Favipiravir is an antiviral drug that acts by increasing the genome-wide mu ...

Oxford University Press (OUP)2017

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Antiviral

HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

Breaking the Fourth Wall: Modulating Quaternary Associations for Protein Regulation and Drug Discovery

A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1

Two-photon triggered photorelease of caged compounds from multifunctional harmonic nanoparticles

Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism

Introducing tolerance to foreign and partly foreign proteins by erythrocyte binding and artificial glycosylations

Genetics of human susceptibility to active and latent tuberculosis: present knowledge and future perspectives

Optimized Background Regimen for Treatment of Active Tuberculosis with the Next-Generation Benzothiazinone Macozinone (PBTZ169)

Drug Repurposing Approach Identifies a Synergistic Drug Combination of an Antifungal Agent and an Experimental Organometallic Drug for Melanoma Treatment

The Combined Effect of Oseltamivir and Favipiravir on Influenza A Virus Evolution

Graph Chatbot

Chattez avec Graph Search

Introducing tolerance to foreign and partly foreign proteins by erythrocyte binding and artificial glycosylations

Two-photon triggered photorelease of caged compounds from multifunctional harmonic nanoparticles

A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1

Genetics of human susceptibility to active and latent tuberculosis: present knowledge and future perspectives

Optimized Background Regimen for Treatment of Active Tuberculosis with the Next-Generation Benzothiazinone Macozinone (PBTZ169)

The Combined Effect of Oseltamivir and Favipiravir on Influenza A Virus Evolution

HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

Breaking the Fourth Wall: Modulating Quaternary Associations for Protein Regulation and Drug Discovery

Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism

Drug Repurposing Approach Identifies a Synergistic Drug Combination of an Antifungal Agent and an Experimental Organometallic Drug for Melanoma Treatment