Concept
Syndrome de Turner
Publications associées (19)
Acute and Long-Term Effects of Aortic Compliance Decrease on Central Hemodynamics: A Modeling Analysis
Nikolaos Stergiopoulos, Georgios Rovas, Vasiliki Bikia, Stamatia Zoi Pagoulatou
Aortic compliance is an important determinant of cardiac afterload and a contributor to cardiovascular morbidity. In the present study, we sought to provide in silico insights into the acute as well as long-term effects of aortic compliance decrease on cen ...
FRONTIERS MEDIA SA2021DNA-segment-capture model for loop extrusion by structural maintenance of chromosome (SMC) protein complexes
Paolo De Los Rios, Alessandro Barducci
Cells possess remarkable control of the folding and entanglement topology of long and flexible chromosomal DNA molecules. It is thought that structural maintenance of chromosome (SMC) protein complexes play a crucial role in this, by organizing long DNAs i ...
2019Delivery of CRISPR/Cas9 using AAV-PHP.B in the inner ear leads to allele-specific inactivation of the mutated Tmc1 allele and protects auditory function in Beethoven mice
Bernard Schneider, Paola Andrea Solanes Vega, Sofia Carmen Suzanne Spataro
Hearing Loss (HL) is the most prevalent sensorineural disorder, affecting 360 million people worldwide. As genetic causes lead to 50% of pre-lingual deafness, gene therapy is considered as a potential therapeutic strategy. Mutations in the TMC1 gene are li ...
MARY ANN LIEBERT, INC2019Identifying 22q11.2 Deletion Syndrome and Psychosis Using Resting-State Connectivity Patterns
Dimitri Nestor Alice Van De Ville, Maude Schneider, Marie Schaer, Jonas Richiardi
The clinical picture associated with 22q11.2 deletion syndrome (22q11DS) includes mild mental retardation and an increased risk of schizophrenia. While the clinical phenotype has been related to structural brain network alterations, there is only scarce in ...
Springer Verlag2014Dermal collagen and lipid deposition correlate with tissue swelling and hydraulic conductivity in murine primary lymphedema
Melody Swartz, Joseph Rutkowski
Primary lymphedema is a congenital pathology of dysfunctional lymphatic drainage characterized by swelling of the limbs, thickening of the dermis, and fluid and lipid accumulation in the underlying tissue. Two mouse models of primary lymphedema, the Chy mo ...
American Society for Investigative Pathology2010RhoV, a Potential Notch Target Gene in Murine Skin, Does not Play an Essential Role in Epidermis Development and Homeostasis
The evolutionarily conserved Notch signaling cascade plays a pivotal role in the regulation of many fundamental processes such as stem cell maintenance, proliferation, and differentiation. Recently, we aimed to identify downstream target genes regulated by ...
EPFL2010Chromosomal Number Aberrations and Transformation in Adult Mouse Retinal Stem Cells In Vitro
Freddy Radtke, Ivan Stamenkovic
Purpose. The potential of stem cells (SCs) as a source for cell-based therapy on a wide range of degenerative diseases and damaged tissues such as retinal degeneration has been recognized. Generation of a high number of retinal stem cells (RSCs) in vitro w ...
2009Deviant trajectories of cortical maturation in 22q11.2 deletion syndrome (22q11DS): A cross-sectional and longitudinal study
Jean-Philippe Thiran, Meritxell Bach Cuadra, Marie Schaer
22q11.2 deletion syndrome (22q11DS) is associated with an increased susceptibility to develop schizophrenia. Despite a large body of literature documenting abnormal brain structure in 22q11DS, cerebral changes associated with brain maturation in 22q11DS re ...
Elsevier2009Genes, Brain Development and Psychiatric Phenotypes in Velo-Cardio-Facial Syndrome
Velo-cardio-facial syndrome (VCFS) has been in the focus of intensive research over the last 15 years. The syndrome represents a homogeneous model for studying the effect of a decreased dosage of genes on the development of brain structure and function and ...
2008A pure population of ectodermal cells derived from human embryonic stem cells
Embryonic stem (ES) cells represent a unique cellular model to recapitulate in vitro early steps of embryonic development and an unlimited cellular source in therapy for many diseases, as well as targets for drug discovery and toxicology screens. Although ...
2008