Concept

Métalloprotéinase matricielle

Publications associées (99)

The TLR4 Agonist Fibronectin Extra Domain A is Cryptic, Exposed by Elastase-2; use in a fibrin matrix cancer vaccine

Jeffrey Alan Hubbell, Mikaël Martino, Alexandre de Titta, Laura Jeanbart, Ziad Julier

Fibronectin (FN) is an extracellular matrix (ECM) protein including numerous fibronectin type III (FNIII) repeats with different functions. The alternatively spliced FN variant containing the extra domain A (FNIII EDA), located between FNIII 11 and FNIII 1 ...

Nature Publishing Group2015

Molecularly Engineered Self-Assembling Membranes for Cell-Mediated Degradation

Jeffrey Alan Hubbell, Daniela Sofia Dias Ferreira, Yi-An Lin

The use of peptide engineering to develop self-assembling membranes that are responsive to cellular enzyme activities is reported. The membranes are obtained by combining hyaluronan (HA) and a rationally designed peptide amphiphile (PA) containing a proteo ...

Wiley-Blackwell2015

Fibrin gels engineered with pro-angiogenic growth factors promote engraftment of pancreatic islets in extrahepatic sites in mice

Jeffrey Alan Hubbell, Mikaël Martino, Alice Anna Tomei

With a view toward reduction of graft loss, we explored pancreatic islet transplantation within fibrin matrices rendered pro-angiogenic by incorporation of minimal doses of vascular endothelial growth factor-A165 and platelet-derived growth factor-BB prese ...

Wiley-Blackwell2015

Cell-mediated Fibre Recruitment Drives Extracellular Matrix Mechanosensing in Engineered Fibrillar Microenvironments

Mahmut Selman Sakar

To investigate how cells sense stiffness in settings structurally similar to native extracellular matrices, we designed a synthetic fibrous material with tunable mechanics and user-defined architecture. In contrast to flat hydrogel surfaces, these fibrous ...

Nature Publishing Group2015

Extracellular matrix-inspired growth factor delivery systems for bone regeneration

Jeffrey Alan Hubbell, Mikaël Martino, Priscilla Suhasna Maithili Briquez

Growth factors are very promising molecules to enhance bone regeneration. However, their translation to clinical use has been seriously limited, facing issues related to safety and cost-effectiveness. These problems derive from the vastly supra-physiologic ...

Elsevier Science Bv2015

A niche role for periostin and macrophages in glioblastoma

Michele De Palma, Mario Leonardo Squadrito

Macrophages facilitate tumour progression, but it is unclear whether this capability is influenced by tumour-initiating cells. Glioblastoma stem cells are now shown to secrete periostin, a matrix protein that recruits protumoral macrophages and enhances gl ...

Nature Publishing Group2015

Neuronal Matrix Metalloproteinase-9 Is a Determinant of Selective Neurodegeneration

Patrick Aebischer, Christopher Towne

Selective neuronal loss is the hallmark of neurodegenerative diseases. In patients with amyotrophic lateral sclerosis (ALS), most motor neurons die but those innervating extraocular, pelvic sphincter, and slow limb muscles exhibit selective resistance. We ...

Elsevier2014

Vascular Modulatory Functions of Macrophages

Michele De Palma, Ioanna Keklikoglou

Monocytes/macrophages have long been regarded as important regulators of angiogenesis and vascular remodeling in both developmental and pathological processes. Historically, the ability of macrophages to promote vascular growth has been primarily attribute ...

Springer2014

The Nano-Scale Mechanical Properties of the Extracellular Matrix Regulate Dermal Fibroblast Function

Jean-Jacques Meister, Boris Hinz, Lara Buscemi Estefanell, Josiane Angèle Charlotte Smith-Clerc

Changes in the mechanical properties of dermis occur during skin aging or tissue remodeling and affect the activity of resident fibroblasts. With the aim to establish elastic culture substrates that reproduce the variable softness of dermis, we determined ...

Nature Publishing Group2014

Role for MMP-9 in stress-induced downregulation of nectin-3 in hippocampal CA1 and associated behavioural alterations

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Michael van der Kooij, Martina Fantin, Céline Fournier

Chronic stress is a risk factor for the development of psychopathologies characterized by cognitive dysfunction and deregulated social behaviours. Emerging evidence suggests a role for cell adhesion molecules, including nectin-3, in the mechanisms that un ...

2014

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