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The cutaneous phototoxic reaction induced by i.v. injection of 5,-10,-15,-20-tetra(m-hydroxyphenyl)chlorin (mTHPC) has been clin. evaluated in patients undergoing photodynamic therapy. These tests were performed on the backs of 23 patients with a solar sim ...
The objective of this study was to unravel the structural properties responsible for the partitioning of solutes in o‐nitrophenyl octyl ether (o‐NPOE)/H2O, a new solvent system for the determination of the partition coefficients of ions. A set of 88 compou ...
Drug-eluting stents are cardiovascular stents able to release a medical drug after implantation. The medical drug is, in general, aimed at healing the vascular tissues injured after implantation and to prevent restenosis. In spite of their apparent simplic ...
As other monosaccharide mimics such as the azasugars and the carbasugars (with nitrogen and carbon atom, respectively, instead of oxygen atom in the ring) the thiosugars (with sulfur atom instead of oxygen atom in the ring) have gained importance in glycob ...
Materials for use in controlled release of water sol. macromol. drugs, such as proteins and polysaccharides, were developed, i.e. (1) a material that would be phase compatible with the water sol. drug; (2) a material that would induce a reduced inflammator ...
Protein design is important to develop new drugs. As such, a knowledge of the correct model to use to design novel proteins is of the utmost importance. Here we show that a simple model where the solvent degrees of freedom are (semi)explicitly taken into a ...
The term 'microbial persistence' describes a phenomenon whereby microorganisms which are drug-susceptible when tested outside the body are nevertheless capable of surviving within the body despite intensive therapy with the appropriate antimicrobial drug. ...
Attention has been focused on the possibility of an interaction between the endorphinergic system and ethanol intake. In the present study, the effects of subcutaneous (SC) administration of beta-endorphin (beta-E) (0.25, 1 and 5 micrograms/kg) and/or nalo ...
