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Publications associées (95)

Spatially selective activation of the visual cortex via intraneural stimulation of the optic nerve

Silvestro Micera, Diego Ghezzi, Fiorenzo Artoni, Paola Vagni, Vivien Gaillet, Ariastity Mega Pratiwi, Dario Lipucci Di Paola

Retinal prostheses can restore a functional form of vision in patients affected by dystrophies of the outer retinal layer. Beyond clinical utility, prostheses for the stimulation of the optic nerve, the visual thalamus or the visual cortex could also serve ...

2019

Cryo-EM structure of the rhodopsin-G alpha i-beta gamma complex reveals binding of the rhodopsin C-terminal tail to the g beta subunit

Henning Paul-Julius Stahlberg, Inayathulla Mohammed

One of the largest membrane protein families in eukaryotes are G protein-coupled receptors (GPCRs). GPCRs modulate cell physiology by activating diverse intracellular transducers, prominently heterotrimeric G proteins. The recent surge in structural data h ...

eLife Sciences Publications, Ltd2019

Validation of a Foldable and Photovoltaic Wide-Field Epiretinal Prosthesis

Diego Ghezzi

Inspired by intra ocular lenses, we designed a foldable and wide-field epiretinal prosthesis capable of achieving a wireless photovoltaic stimulation of retinal ganglion cells with a remarkable increase in its retinal coverage and in the number of stimulat ...

2018

Impact of MCT1 Haploinsufficiency on the Mouse Retina

Pierre Magistretti, Sylvain Eric Lengacher, Luc Pellerin

The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1+/- heterozygotes, which express half of the normal complement of MCT1. The MCT1(+/-) retina devel ...

SPRINGER INTERNATIONAL PUBLISHING AG2018

Soft Three-dimensional self-opening intraneural peripheral interface for optic nerve stimulation

Diego Ghezzi, Eleonora Borda, Marta Jole Ildelfonsa Airaghi Leccardi

Retinitis Pigmentosa and age-related macular degeneration are two of the principal causes of blindness in industrialized countries, for which there is still no established prevention, treatment or cure. In the past decade, retinal prostheses emerged as pro ...

2018

Upper stimulation threshold for retinal ganglion cell activation

Diego Ghezzi

Objective. The existence of an upper threshold in electrically stimulated retinal ganglion cells (RGCs) is of interest because of its relevance to the development of visual prosthetic devices, which are designed to restore partial sight to blind patients. ...

2018

Photovoltaic stimulation of retinal ganglion cells with wide-field epiretinal prosthesis

Diego Ghezzi, Kevin Sivula, Marta Jole Ildelfonsa Airaghi Leccardi, Laura Ferlauto, Naïg Aurelia Ludmilla Chenais

Retinal prostheses have become in the past decade a promising and realistic technology to restore vision. Nonetheless, sight restoration with retinal prostheses in a clinically relevant perspective requires resolution and implantation challenges not yet ac ...

2017

Image reproduction with compensation of luminance adaptation

Mahmut Sami Arpa

We introduce an image reproduction model that retargets colors for printing purposes to ensure similar luminance perception under photopic and scotopic vision. Our model is based on the physiological functioning of the rod and cone cells in the retina in v ...

Springer London Ltd2017

How Rhodopsin Tunes the Equilibrium between Protonated and Deprotonated Forms of the Retinal Chromophore

Ursula Röthlisberger, Siri Camee van Keulen, Alicia Solano

Rhodopsin is a photoactive G-protein-coupled receptor (GPCR) that converts dim light into a signal for the brain, leading to eyesight. Full activation of this GPCR is achieved after passing through several steps of the protein's photoactivation pathway. Ke ...

2017

Pull-Out Behavior of CFRP Single-Strap Ground Anchors

Thomas Keller, Anastasios Vassilopoulos, Haifeng Fan

Pull-out experiments were performed on four carbon fiber-reinforced polymer (CFRP) ground anchors simulating their applications in rock and soil. The CFRP tendons used in these anchors comprise a single-strap end on both ground and air sides. On the ground ...

American Society of Civil Engineers2017

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