Concept

Lipoprotéine de basse densité

Publications associées (182)

Semiconductor defects at the 4H-SiC(0001)/SiO2 interface

We study several semiconductor defects at the 4H-SiC(0 0 0 1)/SiO2 interface within a spin-polarized generalized-gradient density-functional approach for identifying candidate defects responsible for the high density of interface defects measured in the up ...

2007

LRP1 functions as an atheroprotective integrator of TGFbeta and PDFG signals in the vascular wall: implications for Marfan syndrome

Johan Auwerx

BACKGROUND: The multifunctional receptor LRP1 controls expression, activity and trafficking of the PDGF receptor-beta in vascular smooth muscle cells (VSMC). LRP1 is also a receptor for TGFbeta1 and is required for TGFbeta mediated inhibition of cell proli ...

2007

Energetic particle physics studies on Alcator C-Mod

Ambrogio Fasoli, Yu Lin

Energetic particle physics is studied in Alcator C-Mod in reactor relevant regimes with high density and equilibrated electron and ion temperatures. Stable Alfven eigenmodes are excited with low-power active magnetohydrodynamic antennas in the absence of a ...

2007

A global collisionless PIC code in magnetic coordinates

Olivier Sauter, Laurent Villard, Kurt Appert, Trach-Minh Tran, Alberto Bottino, Sébastien Jolliet, Ben McMillan, Paolo Angelino

A global plasma turbulence simulation code, ORB5, is presented. It solves the gyrokinetic electrostatic equations including zonal flows in axisymmetric magnetic geometry. The present version of the code assumes a Boltzmann electron response on magnetic sur ...

Elsevier2007

Collection of blood and plasma from the mouse

Johan Auwerx

There are many elements in plasma that can act as surrogate markers of the physiological well-being of a mouse, thus making the collection of blood and plasma a general technique with many applications in mouse phenotyping. For example, the presence of cer ...

Wiley2006

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Johan Auwerx, Kristina Schoonjans, Chikage Mataki

While bile acids (BAs) have long been known to be essential in dietary lipid absorption and cholesterol catabolism, in recent years an important role for BAs as signalling molecules has emerged. BAs activate mitogen-activated protein kinase pathways, are l ...

2006

Characterization of Fibra-Cel® packed-bed bioreactors for the culture of CHO cells

Frédéric Meuwly

Today, more than 30 products using a manufacturing process based on mammalian cell culture have been approved for human therapy. Most of these products are currently supplied with stirred tank bioreactors operated in batch or fed-batch mode. However, the b ...

EPFL2006

Visceral obesity is associated with high levels of serum squalene

Johan Auwerx

OBJECTIVE: To investigate the impact of visceral obesity on cholesterol metabolism in normoglycemic offspring of patients with type 2 diabetes. RESEARCH METHODS AND PROCEDURES: The proportion of intra-abdominal fat (IAF) was measured by abdominal computer ...

2006

Mathematical and numerical models for transfer of low-density lipoproteins through the arterial walls: A new methodology for the model set up with applications to the study of disturbed lumenal flow

Alfio Quarteroni, Paolo Zunino

In this work we introduce and discuss several mathematical models, based on partial differential equations, devised to study the coupled transport of macromolecules as low-density lipoproteins in the blood stream and in the arterial walls. These models are ...

2005

Study of a new PPARgamma2 promoter polymorphism and haplotype analysis in a French population

Johan Auwerx

Peroxisome proliferator-activated receptor-gamma (PPARgamma) plays a role in adipocyte differentiation and insulin sensitization. We identified and characterized a new C/T substitution at position -689 (-689C>T) in the P2 promoter of PPARgamma in a putativ ...

2005

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