Concept

Thermogenèse

Publications associées (18)

Toward contactless human thermal monitoring: A framework for Machine Learning-based human thermo-physiology modeling augmented with computer vision

Alexandre Massoud Alahi, Dolaana Khovalyg, Mohamed Ossama Ahmed Abdelfattah, Mohamad Rida

The transition towards a human-centered indoor climate is beneficial from occupants’ thermal comfort and from an energy reduction perspective. However, achieving this goal requires the knowledge of the thermal state of individuals at the level of body part ...

2023

Trans-anethole Induces Thermogenesis via Activating SERCA/SLN Axis in C2C12 Muscle Cells

Sulagna Mukherjee

Recently, adaptive non-shivering thermogenesis has attracted considerable attention because it can elevate energy expenditure and help treat obesity. Despite the numerous reports related to UCP1-driven thermogenesis, little is known regarding UCP1-independ ...

KOREAN SOC BIOTECHNOLOGY & BIOENGINEERING2022

Dynamics of metabolic rate in male individuals due to the meal and regular office activities

Dolaana Khovalyg, Jiyoung Kwak

Metabolic rate is one of the main parameters affecting the thermal balance of the human body and perception of thermal comfort. Typically, we consider a constant value for a specific type of activity (sitting quiet, standing, etc.) despite the time of the ...

TU Delft2022

SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice

Johan Auwerx

Brown adipose tissue plays a central role in the regulation of the energy balance by expending energy to produce heat. NAD(+)-dependent deacylase sirtuins have widely been recognized as positive regulators of brown adipose tissue thermogenesis. However, he ...

NATURE PORTFOLIO2022

Colchicine stimulates browning via antagonism of GABA receptor B and agonism of? 3-adrenergic receptor in 3T3-L1 white adipocytes

Sulagna Mukherjee

Colchicine has been used for therapeutic purposes and has attracted considerable attention because of its association with tubulin and the inhibition of small tubular polymerization. Although several studies have examined the possible preventive role of co ...

ELSEVIER IRELAND LTD2022

Inter-Individual Variability of Human Thermoregulation: Towards Personalized Ergonomics of the Indoor Thermal Environment

Dolaana Khovalyg

Indoor temperature maintenance represents a large portion of the energy used in buildings and reducing dependence on energy-intensive thermal conditioning systems would benefit our fight against climate change as well as potentially have positive effects o ...

2022

Crosstalk between Drp1 phosphorylation sites during mitochondrial dynamics and metabolic adaptation

Miriam Valera Alberni

Mitochondria are highly dynamics organelles that undergo coordinated cycles of fission and fusion, referred to as mitochondrial dynamics. Mitochondrial dynamics regulate mitochondrial bioenergetics and allow cells to adapt to changing cellular stresses and ...

EPFL2020

Mfn2 is critical for brown adipose tissue thermogenic function

Carlos Canto Alvarez, Joanna Ratajczak, Miriam Valera Alberni

Mitochondrial fusion and fission events, collectively known as mitochondrial dynamics, act as quality control mechanisms to ensure mitochondrial function and fine-tune cellular bioenergetics. Defective mitofusin 2 (Mfn2) expression and enhanced mitochondri ...

Wiley2017

beta-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue

Kristina Schoonjans

beta-Klotho (encoded by Klb) is the obligate coreceptor mediating FGF21 and FGF15/19 signaling. Klb(-/-)mice are refractory to beneficial action of pharmacological FGF21 treatment including stimulation of glucose utilization and thermogenesis. Here, we inv ...

Amer Soc Clinical Investigation Inc2017

A systems perspective on brown adipogenesis and metabolic activation

Bart Deplancke, Magda Zachara, Rachana Narendra Pradhan

Brown adipocytes regulate energy expenditure via mitochondrial uncoupling. This makes these fat cells attractive therapeutic targets to tackle the burgeoning issue of obesity, which itself is coupled to insulin resistance, type 2 diabetes, cardiovascular a ...

Wiley-Blackwell2017

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