Concept

Hyperpolarization (biology)

Publications associées (47)

Ricca's factors as mobile proteinaceous effectors of electrical signaling

Leaf-feeding insects trigger high-amplitude, defense-inducing electrical signals called slow wave potentials (SWPs). These signals are thought to be triggered by the long-distance transport of low molecular mass elicitors termed Ricca's factors. We sought ...

CELL PRESS2023

Design and performance of a small bath cryostat with NMR capability for transport of hyperpolarized samples

Andrea Capozzi

As of today, dissolution Dynamic Nuclear Polarization (dDNP) is the only clinically available hyperpolarization technique for C-13-MRI. Despite the clear path towards personalized medicine that dDNP is paving as an alternative and/or complement to Positron ...

NATURE PORTFOLIO2022

Cell Type-Specific Membrane Potential Changes in Dorsolateral Striatum Accompanying Reward-Based Sensorimotor Learning

Carl Petersen, Sylvain Crochet, Tanya C Sippy

The striatum integrates sensorimotor and motivational signals, likely playing a key role in reward-based learning of goal-directed behavior. However, cell type-specific mechanisms underlying reinforcement learning remain to be precisely determined. Here, w ...

OXFORD UNIV PRESS2021

Scaling analyses for hyperpolarization transfer across a spin-diffusion barrier and into bulk solid media

David Lyndon Emsley, Arthur César Pinon, Bradley Floyd Chmelka

By analogy to heat and mass transfer film theory, a general approach is introduced for determining hyperpolarization transfer rates between dilute electron spins and a surrounding nuclear ensemble. These analyses provide new quantitative relationships for ...

ROYAL SOC CHEMISTRY2021

Deep learning-based reduced order models in cardiac electrophysiology

Alfio Quarteroni, Andrea Manzoni

Predicting the electrical behavior of the heart, from the cellular scale to the tissue level, relies on the numerical approximation of coupled nonlinear dynamical systems. These systems describe the cardiac action potential, that is the polarization/depola ...

PUBLIC LIBRARY SCIENCE2020

Low-dimensional firing-rate dynamics for populations of renewal-type spiking neurons

Tilo Schwalger

The macroscopic dynamics of large populations of neurons can be mathematically analyzed using low-dimensional firing-rate or neural-mass models. However, these models fail to capture spike synchronization effects and nonstationary responses of the populati ...

AMER PHYSICAL SOC2020

On the stability and necessary electrophoretic mobility of bare oil nanodroplets in water

Sylvie Roke, Saranya Pullanchery Sankara Narayanan, Halil Ibrahim Okur, Hilton Barbosa De Aguiar, Sergey Kulik

Hydrophobic oil droplets, particles, and air bubbles can be dispersed in water as kinetically stabilized dispersions. It has been established since the 19th century that such objects harbor a negative electrostatic potential roughly twice larger than the t ...

AMER INST PHYSICS2020

A stick-slip/inchworm hybrid rotary piezo motor based on a symmetric triangular driving mechanism

Dongdong Zheng, Yuxin Peng

A stick-slip/inchworm hybrid rotary piezomotor based on a symmetric triangular driving mechanism, which can simultaneously achieve the benefits of both stick-slip and inchworm motors, was reported in this letter. It is based on the principle of stick-slip ...

2019

Nonlinear microscopy for temporally and spatially resolved label-free imaging of living cells

Marie Eve Pascale Didier

The human brain consists of approximately a hundred billion of neurons that communicate through a unique series of biochemical and electrical processes. When neuronal networks are solicited, electrochemical processes happen involving millions of cells with ...

EPFL2018

Transportable hyperpolarized metabolites

David Lyndon Emsley, Geoffrey Bodenhausen, Aurélien Bornet, Sami Jannin, Aaron James Rossini, Jonas Milani, Basile Vuichoud, Xiao Ji, David Benjamin Roger Antoine Gajan

Nuclear spin hyperpolarization of C-13-labelled metabolites by dissolution dynamic nuclear polarization can enhance the NMR signals of metabolites by several orders of magnitude, which has enabled in vivo metabolic imaging by MRI. However, because of the s ...

Nature Publishing Group2017

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