Concept

Addition nucléophile

Publications associées (133)

Organocatalysis: Fundamentals and Comparisons to Metal and Enzyme Catalysis

Catalysis fulfills the promise that high-yielding chemical transformations will require little energy and produce no toxic waste. This message is carried by the study of the evolution of molecular catalysis of some of the most important reactions in organi ...

Mdpi Ag2016

Key Players in I-DmoI Endonuclease Catalysis Revealed from Structure and Dynamics

Homing endonucleases, such as I-DmoI, specifically recognize and cleave long DNA target sequences (∼20 bp) and are potentially powerful tools for genome manipulation. However, inefficient and off-target DNA cleavage seriously limits specific editing in com ...

American Chemical Society2016

Elastomers with tunable dielectric and electromechanical properties

Frank Nüesch

Novel electroresponsive silicone elastomers modified with nitrile groups are presented, whose dielectric permittivity (epsilon') is tuned from epsilon' = 4.3 to epsilon' = 17.4. They are prepared in a one-step process starting from a high molecular weight ...

Royal Soc Chemistry2016

Preparation and commissioning of LHCb for the Run II of LHC

The LHCb experiment has performed very well during the Run I of the LHC, producing a large number of relevant physics results on a wide range of topics. The preparation and commissioning of the LHCb experiment for Run II is discussed here, with special emp ...

Elsevier Science Bv2016

1-Alkynyltriazenes as Functional Analogues of Ynamides

Rosario Scopelliti, Kay Severin, Jérôme Waser, Gregor Kiefer, Sophie Lucie Racine, Loïc Nicolas Jeanbourquin, Florian Gérald Abela, Daniele Perrotta

The chemical reactivity of 1-alkynyltriazenes has been investigated and is found to parallel the reactivity of ynamides. The similarity in reactivity of these two classes of compounds is demonstrated by addition reactions with acids, by cycloaddition react ...

Wiley-Blackwell2015

Enantioselective Synthesis of Putative Lipiarmycin Aglycon Related to Fidaxomicin/Tiacumicin B

Jieping Zhu

An enantioselective synthesis of a putative lipiarmycin aglycon was accomplished and features: 1) Brown’s enantioselective alkoxyallylboration and allylation of aldehydes, 2) chain elongation by iterative Horner–Wadsworth– Emmons olefination, 3) Evans aldo ...

Wiley-Blackwell2015

Alkynylation with Hypervalent Iodine Reagents

Jérôme Waser

Alkynes are among the most versatile functional groups in organic synthesis. They are also frequently used in chemical biology and materials science. Whereas alkynes are traditionally added as nucleophiles into organic molecules, hypervalent iodine reagent ...

Springer Verlag2015

Enantioselective Synthesis of Homoallylic Azides and Nitriles via Palladium-Catalyzed Decarboxylative Allylation

Jérôme Waser, Paola Caramenti, Maria Victoria Vita

Azides and nitriles are important building blocks for the synthesis of nitrogen-containing bioactive compounds. The first example of enantioselective palladiumcatalyzed decarboxylative allylation of alpha-azido and cyano beta-ketoesters is reported. Indano ...

American Chemical Society2015

Fine-tuning of the dielectric properties of polysiloxanes by chemical modification

Frank Nüesch

A series of novel polysiloxanes is presented, the glass transition temperatures and dielectric properties of which are systematically fine-tuned by utilizing thiol-ene post-polymerization reactions. The pendant vinyl groups of a high molecular weight polym ...

Royal Soc Chemistry2015

L’invention partagée (Michel Lussault, L’avènement du Monde)

Jacques Lévy

"L’avènement du Monde" by Michel Lussault offers a substantial and innovative spatial theory of an object, the World. Space is addressed both as a technical system and a society, and each of these approaches generates an overall, panoramic view. In additio ...

2015

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