Concept

Ophidia

Publications associées (4)

Regulatory Switches Underlie Hoxd Gene Activation in Tetrapod Limbs

Accurate spatio-temporal control of Hox cluster genes expression is critical for the proper organization of body structures during vertebrate embryogenesis. In the limbs, Hoxd genes are critical in setting up the proximodistal and anteroposterior axes. Sev ...

EPFL2013

Changes in Hox genes' structure and function during the evolution of the squamate body plan

Denis Duboule

Hox genes are central to the specification of structures along the anterior-posterior body axis, and modifications in their expression have paralleled the emergence of diversity in vertebrate body plans. Here we describe the genomic organization of Hox clu ...

Nature Publishing Group2010

Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations

Denis Duboule

In the limb bud the 5' members of the Hox-4 gene cluster are expressed in a nested set of overlapping domains which are progressively restricted in the posterior and distal directions. These domains arise early in limb bud development and come to approxima ...

1992

The mouse Hox-1.4 gene: primary structure, evidence for promoter activity and expression during development

Denis Duboule

This study reports the structure of the mouse homeobox-containing gene Hox-1.4 of the HOX-1 cluster, as well as its expression pattern during embryonic and fetal development. The overall structure of this gene includes two major exons, the second of which ...

1989

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